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Completed

NCT Number: NCT01708083

Polymorphids an mRNA Expression in Obese Genes

Fat tissue from omenta, thigh and abdomen taken under anesthesia on subjects undergoing laparoscopic surgery, cholecystectomy, reflux surgery or gastric by-pass (GBP).

Are there any difference in polymorphids and/or mRNA expression in genes significant for developing obesity, between normal weight and obese individuals, with or without diabetes typ 2 .

Are there any difference in polymorphids and/or mRNA expression in different types of fat tissue

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Key information

Conditions

Polymorphism mRNA Expression

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ersta hospital, Stockholm, Stockholm County Council, Sweden

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 18 years or older
  • laparoscopic surgery (Gastric by-pass, cholecystectomy, antireflux surgery)
  • Normal weight without type 2 diabetes BMI 18-25
  • Obese without type 2 diabetes BMI>35
  • Obese with type 2 diabetes BMI>35

Exclusion criteria

  • under 18 years
  • open surgery
  • pregnancy
  • BMI >27-<35

Treatment and study plan

Primary outcomes

  1. Differences in polymorphids and/or mRNA expression in genes, significant for developing obesity and type 2 diabetes, between patients with normal weight and obesity

    Time frame: approximatly 30 minutes after start of operation

    fat biopsy taken from abdomen, omenta and thigh at surgery

  2. Difference in polymorphids and/or mRNA expression in different types of fat tissue in patients with normal weight or obesity with or without diabetes type 2

    Time frame: approximatly 30 minutes after start of operation

    fat biopsy; abdomen, omenta and thigh taken at surgery

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Registry information

Official study title

Polymorphids and mRNA Expression in Genes, Significant for Developing Obesity and Typ II Diabetes in Different Types/Localisations of Fat Tissue

Important dates

Study start
2010
Primary completion
2013
Study completion
2013
First posted
Oct 16, 2012
Registry last updated
Aug 22, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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