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NCT Number: NCT07418788

Polymeric Nano Calcium Fluoride Varnish, Diode Laser, and Their Combination for Dentin Hypersensitivity

The aim of the study is to assess the effect of polymeric nano calcium fluoride Varnish (Oli-NANO seal), 976 nm diode laser solely and combination of both therapies in the treatment of dentin hypersensitivity

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Dentin Hypersensitivity, Non-carious Cervical Lesions Dentin Sensitivity Gingival Recession Localized Moderate Stomatognathic Diseases Tooth Diseases

Age range

30 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dental medicine for Girls

Cairo, 4470351, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Medically free
  • Non-smokers
  • Co-operative patients who will be interested in participating in the study and willing to sign the informed consent.
  • Availability of patients for 1 year

Exclusion criteria

  • Patients currently using analgesic, anti-inflammatory medications, sedatives, tranquilizers, anticonvulsants, or any other medications that could potentially alter pain perception.
  • Patients undergoing orthodontic treatment.
  • Patients using desensitizing toothpaste
  • Patients receiving dentin hypersensitivity (DH) treatment
  • Pregnant or lactating women
  • Patients have high consumption of sour and acidic food
  • Patients who had undergone professional desensitizing therapy during the previous 3 months.

Treatment and study plan

Olinano seal

Other

The OliNANO seal is "varnish-like" shield which is based on nanotechnology that allows an optimum adhesion to enamel and dentin, it could be used as an effective desensitizing agent by forming a protective layer that occludes the dentinal tubules which can be effective for a year as mentioned by the manufacturer. Polymeric nano calcium fluoride varnish consists of four main components, silicone polymer, NANO-fluorapatite, nano-calcium fluoride and amine fluoride (Olaflur)

Diode laser

Device

increase in the metabolic activity of odontoblasts. Thus, obliteration of the dentinal tubules and formation of tertiary dentin.

Olinano seal and Diode Laser

Other

Combined methods have been also evaluated in some previous studies. It showed more effect in reducing Dentin hypersensitivity than using every treatment solely

Primary outcomes

  1. Pain severity

    Time frame: Before the treatment (Baseline), after the first session (T1), second session (T2) will be done after a week from the first session, after 3 months (T3), 6 months (T6), 9 months (T9) and 12 months (T12)

    The pain will be assessed using the (VAS) scale. The VAS is a scale that allows the patient to self-assess the pain felt by means of a line in which the patient marks the pain level "no pain" to the "maximum pain". 0: low pain, 1 - 3: moderate pain: 4 - 6, intense pain: 7 - 9, extremely intense pain: 10

Sponsors and collaborators

Lead sponsor

Faculty of Dental Medicine for Girls

Other Gov

Registry information

Official study title

Efficacy of Polymeric Nano Calcium Fluoride Varnish, Diode Laser Individually and in Combination in the Treatment of Dentin Hypersensitivity.

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Feb 18, 2026
Registry last updated
Feb 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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