Point of Care Testing of Cholinesterase Activity During Burn- and Polytrauma

Goal of this study is to measure serum cholinesterase activity in patients with traumatic and/or burns injury admitted to the emergency room by using point-of- care-test system (POCT). Serum cholinesterase activity, measured using POCT system, might play an important role in the early diagnosis and prediction of patient outcome in trauma-induced systemic inflammation.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Trauma Burns Butyrylcholinesterase deficiency Multiple Trauma Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anaesthesia, Intensive Care Medicine and Pain Therapy, BG Trauma Center Ludwigshafen

Ludwigshafen am Rhein, Rhineland-Palatinate, 67071, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

signed written consent
18 years and older
severe trauma (ISS > 15)
burns injury (2. degree more than 15% body surface or 3 degree more than 10% body surface)
SIRS

Exclusion criteria

not fulfilling the inclusion criteria
failure to adhere

Treatment and study plan

Primary outcomes

Early diagnosis of the systemic inflammation by using the serum cholinesterase activity measurement

Time frame: after completed patient recruitment, 1 year

By using Point-of-care measurement of serum cholinesterase activity (U/l) and by observing a change in the enzyme activity over time (reduction of serum cholinesterase activity within the first 6 hours after traumatic injury) would allow an additional tool in early diagnosis and treatment of systemic inflammation.

Secondary outcomes

correlation of the cholinesterase activity and the trauma/disease severity scores

Time frame: after completed patient recruitment, 1 year

To evaluate the correlation of the serum cholinesterase activity change with the trauma severity, the obtained serum cholinesterase activities (U/l) will be compared to the trauma severity scores (ISS, %TBSA).

Sponsors and collaborators

Lead sponsor

University Hospital Heidelberg

Other

Collaborators

BG Trauma Center Ludwigshafen

Registry information

Acronym: POCCET

Important dates

Study start: 2016
Primary completion: 2018
Study completion: 2018
First posted: Feb 25, 2016
Registry last updated: Apr 16, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed