Skip to main content
OpenTrials
Completed

NCT Number: NCT01199913

POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia

The use of desflurane in elderly subjects (>65 years old) undergoing general anesthesia with endotracheal intubation will result in decreased POCD compared to sevoflurane if the patient's MAP is within 20% of the patient's baseline and the cerebral suppression state index stays within the moderately anesthetized range during general anesthesia.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

1. Postoperative Cognitive Dysfunction

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Loma Linda University

Loma Linda, California, 92354, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients (>65 years old)
  • Scheduled for elective surgery requiring general anesthesia at LLUMC HSH
  • Airway management expected to include endotracheal intubation
  • Expected surgical duration 120 to 240 minutes

Exclusion criteria

  • Pre-existing significant psychiatric disease or mental status changes
  • Clinically significant cardiovascular, respiratory, hepatic, renal,neurological, psychiatric, or metabolic disease
  • Patient's weighing >50% ideal body weight
  • Men: Ideal Body Weight (in kilograms) = 50 + 2.3 kg per inch over 5 feet
  • Women: Ideal Body Weight (in kilograms) = 45.5 + 2.3kg per inch over 5 feet
  • Patients who have undergone a general anesthetic within the past 7 days
  • Patient refusal

Treatment and study plan

The intervention will be Mini-Mental Status Examination (MMSE)

Other

A questionnaire given to the study patient before and after the anesthetic at 1, 6 and 24 hours.

Primary outcomes

  1. POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia

    Time frame: Both groups will complete the MMSE at 1, 6, and 24 hours after the end of anesthesia or to disharge up to 7 days.

    The primary outcome measure will be changes in cognitive function after anesthesia as measured by MMSE.

Secondary outcomes

  1. Secondary outcome measures will include: 1) time to extubation, anesthetic complications (e.g. coughing during extubation), 2) time to readiness for discharge from PACU, 3) length of hospital stay, and 4) any postoperative complications.

    Time frame: 24 hours to 7 days

Sponsors and collaborators

Lead sponsor

Loma Linda University

Other

Registry information

Official study title

Incidence of Postoperative Cognitive Dysfunction in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia: A Randomized, Controlled Trial

Important dates

Study start
2010
Primary completion
2014
Study completion
2014
First posted
Sep 13, 2010
Registry last updated
Sep 9, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.