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Completed

NCT Number: NCT03084393

POCD: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

To study on the Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12. To explore whether the gene polymorphism and the concentrations of plasma homocysteine, folic acid and vitamin B12 could be used as predictor(s) of POCD and to provide reference for POCD prevention, early detection and timely diagnosis and treatment.

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Key information

Conditions

Postoperative Cognitive Dysfunction Cognition Disorders Cognitive Dysfunction Mental Disorders Neurocognitive Disorders Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Cognitive Complications Postoperative Complications

Age range

60 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anesthesia of the Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Non-cardiac surgery patients;
  • Age is greater than or equal to 60 years old;
  • Han Nationality, mother tongue is chinese;
  • The MMSE score: Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;
  • The Geriatric Depression Scale (GDS) grade 1 or 2;
  • The important function without serious heart, brain, liver, kidney, lung and other organs;
  • The ASA class I or II;
  • The people signed informed consent.

Exclusion criteria

  • The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.;
  • Had severe head and face disease, trauma history or history of surgery;
  • The serious body disease and tobacco, wine and other substance abuse history;
  • The presence of malignant tumor with shorter survival disease.

Treatment and study plan

Primary outcomes

  1. the neuropsychological tests

    Time frame: 1 day before surgery(baseline)

    the neuropsychological tests to measure cognitive function, including the Trail Making Test, the Grooved Pegboard Test, the Digit Span Test, the Number-Symbol Replacement Test,the Finger Tapping Test, the Word Fluency Test and the Building Block Test.

  2. Mini-Mental score examination [MMSE]

    Time frame: 1 day before surgery(baseline)

    Mini-Mental score examination [MMSE] used for screening of dementia

  3. the neuropsychological tests

    Time frame: within the first 7 days (plus or minus 2 days) after surgery

    the neuropsychological tests to measure cognitive function, including the Trail Making Test, the Grooved Pegboard Test, the Digit Span Test, the Number-Symbol Replacement,the Test Finger Tapping Test, the Word Fluency Test and the Building Block Test.

  4. Mini-Mental score examination [MMSE]

    Time frame: within the first 7 days (plus or minus 2 days) after surgery

    Mini-Mental score examination [MMSE] used for screening of dementia

Sponsors and collaborators

Lead sponsor

Xuzhou Medical University

Other

Registry information

Official study title

Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Mar 20, 2017
Registry last updated
Mar 11, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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