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OpenTrials
Completed

NCT Number: NCT02587481

Pneumological Acute Coronary Syndrom (ACS) Phenotyping Aachen

In this open, monocentric, observational study acute coronary syndrom (ACS) patients will be characterized by pneumological examination concerning a concomitant chronic obstructive pulmonary disease (COPD). Often COPD coexists with ACS; therefore ACS patients benefit either from prevention or potential therapy of chronic hypoxia.

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Key information

Conditions

Acute Coronary Syndrom Cardiovascular Diseases Chronic Disease Chronic Obstructive Pulmonary Syndrom Disease Attributes Heart Diseases Infarction Ischemia Lung Diseases Lung Diseases, Obstructive Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Amrei Pelzer

Aachen, North Rhine-Westphalia, 52074, Germany

About this study

In this study patients with either non ST-segment-elevation myocardial infarction (NSTEMI) or ST-segment-elevation myocardial infarction (STEMI) will be included. After amnesis patients will undergo blood withdrawal, blood-gas analysis and examinations concerning pulmonary function (Bodyplethysmography). In addition to routine blood withdrawal for differential blood count, 9 ml blood sample is takenfor molecular analysis of relevant prognostic chronic obstructive pulmonary disease (COPD)-blood based biomarkers, an for establishing a library of biomaterial in form of a biobank.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Written declaration of consent
  • Patients with acute myocardial infarct which can be either non ST-segment-elevation myocardial infarct (NSTEMI) or ST-segment-elevation myocardial infarct (STEMI), in both cases exaggeration of cardiac ischaemic markers

Exclusion criteria

  • Patients not fulfilling the incluson criterias or:
  • Pregnant or breastfeeding women
  • Participation in other studies
  • Persons in depency from the sponsor or working with the sponsor
  • Persons without mental ability or capacity to understand and follow the instructions of the investigator

Treatment and study plan

Primary outcomes

  1. Number of patients with Acute Coronary Syndrom (ACS) and concomitant Chronic Obstructive Pulmonary Disease (COPD)

    Time frame: During 1-2 hours (at time of examination)

Secondary outcomes

  1. Molecular analysis of relevant blood based chronic obstructive pulmonary disease (COPD) biomarkers

    Time frame: An average of 1 day

Sponsors and collaborators

Lead sponsor

RWTH Aachen University

Other

Registry information

Official study title

Pneumological Phenotyping of Acute Coronary Syndrom (ACS) Patients Concerning Concomitant Chronic Obstructive Pulmonary Disease (COPD)

Acronym: PAPA

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Oct 27, 2015
Registry last updated
Nov 20, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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