Enrolling by Invitation

NCT Number: NCT07140003

Pleural Tissue Culture Versus Pleural Fluid Culture in Infected Effusion

comparison between the result of fluid culture and that of pleural tissue culture

Enrolling by Invitation

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Key information

Conditions

Pleural Tissue Culture

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chest Department -Faculty of Medicine

Alexandria, Chest Department, 11511, Egypt

About this study

MICROBIOLOGICAL VALUE OF SONOGRAPHIC GUIDED PLEURAL TISSUE CULTURE PLUS PLEURAL FLUID CULTURE IN PATIENTS WITH INFECTED PLEURAL FLUID

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Exudate neutrophilic pleural fluid aspirate, or met at least one or more of the following criteria: grossly frank purulent, gram stain positive for bacteria, bacterial culture positive, acidic with a pH <7.20, low pleural fluid glucose (<55mg/dL), and CT evidence of pleural infection. Exclusion criteria: Pleural infections by Mycobacterium tuberculosis.Malignant effusion.Coagulation defects.

Treatment and study plan

pleural biopsy

Procedure

To assess whether pleural tissue culture can improve the identification of causative organisms in pleural infections (using the pleural fluid culture), which can aid in selecting appropriate antimicrobial therapy and improve treatment outcomes, thus may provide valuable insights into the utility of pleural tissue culture in managing pleural infection and may guide clinicians in selecting the most appropriate diagnostic approach.

Primary outcomes

initial pleural fluid and parietal pleural tissue

Time frame: 2 weeks

the result of culture
result of culture

Time frame: one month

the result of pleural fluid culture and the pleural tissue culture result

Sponsors and collaborators

Lead sponsor

Alexandria University

Other

Registry information

Official study title

Microbiological Value of Sonographic Guided Pleural Tissue Culture Plus Pleural Fluid Culture in Patients With Infected Pleural Fluid

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Aug 24, 2025
Registry last updated: Aug 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.