Pleural Irrigation With a Novel Devise.

Single-arm pilot trial of the use of intrapleural saline irrigation to treat retained pleural infections for patients with contraindications to standard of care intrapleural enzymatic therapy.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Pleural Effusion Disorder Pleural Diseases Pleural Effusion Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Retained pleural effusion identified via bedside ultrasound within the first 24 hours after chest tube insertion
Patient is contraindicated from receiving intrapleural enzymatic therapy within the first 24 hours after chest tube insertion

Exclusion criteria

Non-infectious cause of pleural fluid analysis findings listed above identified (e.g. malignancy)
Post-procedural empyema or complicated parapneumonic effusion

Treatment and study plan

of intrapleural saline irrigation with CLR irrigator

Device

patients will have a CLRTM port and CLRTM irrigator (CLR Medical, Calverton, MD, USA) added to their chest tube and atrium circuit to facilitate pleural irrigation.

Primary outcomes

Radiographic improvement (reduction in the ammount of pleural effusion messured in centimeters) by bed side ultrasound day 1,2,3,4,5.

Time frame: Daily for 8 days

Study contacts

Contact information is provided by the study sponsor or research team.

Christine Conley

CONTACT

[email protected]

617-632-8386

Sponsors and collaborators

Lead sponsor

Beth Israel Deaconess Medical Center

Other

Registry information

Official study title

A Pilot Assessment of the Safety and Efficacy of Pleural Irrigation for Retained Pleural Infection Using a Novel Irrigation Device

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Dec 11, 2024
Registry last updated: Jul 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting