Pleth Variability Index as a Predictor for Post-induction Hypotension in Elderly Patients

Hypotension after induction of general anesthesia and before surgical stimulation is a prevalent anesthesia-related side effect. The post-induction hypotension disrupts organ perfusion and may cause organ damage particularly acute kidney injury, cerebrovascular stroke, and myocardial ischemia. Post-induction hypotension occurs with greater frequency and severity in the elderly. This is because of aged-related diminished cardiac reserve and impaired autonomic homeostasis. Pleth variability index (PVI) is a software program that measures the dynamic changes of the PI that occurs during a complete respiratory cycle. Our primary outcome is to determine the predictive ability and the optimal cut-off value of pre-anesthesia PVI for predicting elderly patients who are at risk of developing post-induction hypotension

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Key information

Conditions

Post-Induction Hypotension

Age range

65 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Abeer Ahmed Mohamed

Maadi, Cairo Governorate, 11728, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with ASA physical status I or II
patients will receive general anesthesia

Exclusion criteria

Patients with a history of cardiorespiratory disorders
patients with uncontrolled hypertension or cardiac dysrhythmias
Patients with renal or hepatic diseases.
Patients with long-standing diabetes and peripheral vascular diseases.

Treatment and study plan

Pleth variability index for prediction of post-induction hypotension

Device

The use of the baseline Pleth variability index values for prediction of occurrence of post-induction hypotension

Primary outcomes

The accuracy (Area under receiver operating characteristic curves) of pre-induction PVI for prediction of post-induction hypotension

Time frame: before induction of general anesthesia

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Pre-anesthesia Pleth Variability Index as a Predictor for Post-induction Hypotension in Elderly Patients Undergoing General Anesthesia: A Prospective Cohort Study

Important dates

Study start: 2021
Primary completion: 2023
Study completion: 2025
First posted: May 13, 2021
Registry last updated: Apr 8, 2025

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed