Services Hospital Lahore
Lahore, Punjab Province, Pakistan
NCT Number: NCT07377708
This study is testing whether autologous platelet rich plasma (PRP) dressings are more effective than normal saline dressings in treating heel pad injuries caused by motorcycle wheel spokes among children in Pakistan. PRP is prepared from a child's own blood and contains natural growth factors that may help wounds to heal faster. The study compares healing rates, reduction in wound size, and time to complete wound healing between the platelet-rich plasma and saline dressing groups.
Looking for future studies?
Notify Me5 year–12 year
All sexes
Interventional
Not applicable
Lahore, Punjab Province, Pakistan
Motorcycle wheel-spoke injuries occur when the heel or foot becomes entrapped in the spokes of a moving motorcycle, frequently resulting in severe soft tissue damage in children. Healing of these injuries is often prolonged and challenging. Platelet-rich plasma (PRP), prepared from a patient's own blood, contains a high concentration of growth factors that promote tissue regeneration, angiogenesis, and wound contraction. Previous studies in adults with diabetic and chronic ulcers have demonstrated that PRP may accelerate wound healing compared with conventional dressings.
However, evidence supporting the use of PRP in the pediatric population, particularly for heel pad injuries resulting from motorcycle wheel-spoke trauma, remains limited. This randomized controlled trial is designed to evaluate the efficacy of platelet-rich plasma dressing compared with saline dressing in children aged 5 to 12 years presenting with heel pad injuries.
A total of 60 participants will be enrolled and randomly assigned to receive either platelet-rich plasma dressing or saline dressing. Study outcomes will include wound healing within 12 weeks, duration of wound healing in days, and changes in wound size measured in both longitudinal and horizontal dimensions. This trial aims to generate evidence for a more effective and locally feasible wound management strategy for pediatric heel pad injuries in the study setting.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Approximately 10 mL of venous blood is processed in the pathology department to prepare PRP, which is applied as a wound dressing. Dressings are applied over ~4 weeks, with outpatient follow-up until 12 weeks.
Conventional sterile normal saline dressings are applied over ~4 weeks, with outpatient follow-up until 12 weeks.
Time frame: Up to 12 weeks
Wound status based on presence of granulation tissue and measurement of wound size.
Time frame: Up to 12 weeks
Number of days from baseline until there is no further change in wound size.
Time frame: 12 weeks
Calculated as (baseline longitudinal size - size at 12 weeks) ÷ baseline longitudinal size × 100.
Time frame: 12 weeks
Calculated as (baseline horizontal size-sizeat12weeks)÷base line horizontal size X 100
Services Institute of Medical Sciences, Pakistan
Other Gov
A Comparison of Autologous Platelet-Rich Plasma Dressing Versus Saline Dressing in the Management of Pediatric Heel Pad Injuries Due to Motorcycle Wheel-Spoke Trauma
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT07736287
Bone Regeneration, Wound Healing
Bangalore, Karnataka, India
View Trial DetailsNCT06634030
Surgical Wound, Wound Healing
Nashville, Tennessee, United States
View Trial DetailsNCT07627945
Impacted Third Molar, Nervous System Diseases
Kota Bharu, Kelantan, Malaysia
View Trial DetailsNCT06459947
Neurologic Manifestations, Pain
Van, Turkey (Türkiye)
View Trial Details