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OpenTrials
Completed

NCT Number: NCT04149028

Platelet Rich Plasma Injection Into Ovary of Patients With Premature Ovarian Insufficiency

All encountered cases with POI will be assessed and examined then investigated. Eligible cases will be included in the study

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Key information

Conditions

Premature Ovarian Failure Adnexal Diseases Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Gonadal Disorders Infertility Ovarian Diseases Primary Ovarian Insufficiency Urogenital Diseases

Age range

18 year–35 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Adel Elgergawy

Tanta, Egypt

About this study

Patients will be subjected to injection of autologous PRP inside the ovary about 0.5-1 mml by laparoscopy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Premature ovarian insufficiency diagnosed by:
  • FSH> 40 Amenorrhea Menopuasal symptoms Infertility

Exclusion criteria

  • Refusal to participate Secondary POI due chemotherapy, surgery, or radiotherapy Previous treatment with PRP

Treatment and study plan

PRP injection inside the ovary by laparoscoy. The injection volume is 2 ml

Procedure

intraovarian injection of 2 mml of PRP by laparoscopic guide

Primary outcomes

  1. Resumption of ovarian hormonal function

    Time frame: 3-6 months

    Measurement of Estradiol level on Day 3 of cycle

  2. Resumption of ovarian folliclugenesis

    Time frame: 3-6 months

    Assessment of the presence of oocytes by trans vaginal ultrasound on day 3

Secondary outcomes

  1. Resumption of menstruation

    Time frame: 3-6 months

    Occurrence of Menstruation after secondary amenrorrhea by questionnaire

  2. Fertility potential

    Time frame: 3-6 months

    Potential to get pregnant after ICSI procedure

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Important dates

Study start
2019
Primary completion
2022
Study completion
2022
First posted
Nov 4, 2019
Registry last updated
Feb 17, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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