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OpenTrials
Completed

NCT Number: NCT05593731

Platelet Rich Fibrin Versus Melatonin Around Dental Implants

Dental implant is a dental treatment that allow oral rehabilitation for partial and fully edentulous patients. Osteointegration is the factor that control success s or failure of dental implant that can be improved by addition of different adjunctive biological materials. Platelets Rich fibrin plays a significant role in tissue regeneration and wound healing. Melatonin is biological hormone that secreted from pineal gland and played an important role in human growth.

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Key information

Conditions

Patients With Missing Teeth

Age range

18 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 2

Primary location

Faculty of dentistry at MUST

Giza, 02, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • good oral hygiene participants,
  • free of any systemic diseases,
  • Patients' age ranged from 20 to 40 years old.
  • Patients who can complete surgery and the study protocol.
  • Partially edentulous patients in the posterior mandibular region (at least a single-mandibular edentulous area) with periodontal health.

Exclusion criteria

  • patients who had parafunctional habits,
  • current and former smokers, pregnant
  • lactating women
  • unmotivated patients
  • patients with psychological problems
  • patients who were not able to follow the treatment protocol -

Treatment and study plan

dental implants with melatonin gel

Biological

platelet rich fibrin membrane around dental implants

Other names: dental implants with platelet rich fibrin

Primary outcomes

  1. gingival thickness

    Time frame: 6 months

Secondary outcomes

  1. bone density

    Time frame: 6 months

  2. marginal bone loss

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Misr University for Science and Technology

Other

Registry information

Official study title

Evaluation of Local Delivered Platelet Rich Fibrin Versus Melatonin Gel on the Osseointegration of Dental Implant. A Randomized Controlled Clinical Trial

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Oct 25, 2022
Registry last updated
Oct 23, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.