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Completed

NCT Number: NCT00665912

Platelet-Rich and Concentrated Platelet-Poor Plasma to Reduce Air Leak Post-Lobectomy: A Randomized Controlled Trial

The purpose of this study is to determine whether the use of platelet-rich plasma (PRP) and concentrated platelet-poor plasma (PPPc) can reduce the duration of post-operative air leak after lobectomy for lung tumours.

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Key information

Conditions

Lung Cancer Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Western Ontario: Division of Thoracic Surgery

London, Ontario, N6A 5W9, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients requiring a lobectomy

Exclusion criteria

  • Pneumonectomy
  • Sleeve lobectomy
  • Determination of unresectability (prior to the initiation of lobectomy)
  • Wedge resection alone

Treatment and study plan

Standard post-lobectomy wound care plus use of PRP and PPPc prepared by GPS and Plasmax respectively

Procedure

GPS is used to create the platelet rich plasma (PRP). Plasmax is used to create the concentrated platelet-poor plasma (PPPc). Both PRP and PPPc will be used for wound care in the thoracic cavity post-lobectomy.

Standard post-lobectomy wound care

Procedure

Standard post-lobectomy wound care

Primary outcomes

  1. Duration of postoperative air leak

    Time frame: Every 4 hours of postop hospital stay, between 4-6 weeks postop

Secondary outcomes

  1. Incidence of air leak, Prolonged air leak (> days), Complications

    Time frame: Every 4 hours of postop hospital stay, between 4-6 weeks postop

Sponsors and collaborators

Lead sponsor

Zimmer Biomet

Industry

Collaborators

  • University of Western Ontario, Canada

Registry information

Official study title

Platelet-Rich and Concentrated Platelet Poor Plasma to Reduce Air Leak Post Lobectomy: A Randomized Controlled Trial

Important dates

Study start
2008
Primary completion
2010
Study completion
2010
First posted
Apr 24, 2008
Registry last updated
Mar 13, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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