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OpenTrials
Completed

NCT Number: NCT00536068

Platelet Inhibition by Aspirin, Acetaminophen and NSAID

Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the inhibition of platelet aggregation by aspirin, because they all interact with the platelet cyclooxygenase.This may be of great clinical importance because of an increased cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.

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Key information

Conditions

Hemostasis

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kantonsspital Graubünden, Department of Internal Medicine

Chur, CH 7000, Switzerland

About this study

An in vivo study on healthy volunteers with combinations of well established drugs

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers

Exclusion criteria

  • Administration of drugs affecting platelets
  • History of bleeding
  • Gastrointestinal disorders
  • Hypersensitivity to aspirin and/or NSAID
  • Pregnancy and breast feeding

Treatment and study plan

Acetylsalicylic acid, acetaminophen, diclofenac, naproxen, placebo

Drug
  • Acetylsalicylic acid 100mg/po and acetaminophen 3x1g/po for 4 days
  • Acetylsalicylic acid 100mg/po and diclofenac 3x50mg/po for 4 days
  • Acetylsalicylic acid 100mg/po and naproxen 3x250mg/po for 4 days
  • Acetylsalicylic acid 100mg/po and placebo 3x1/po for 4 days

Primary outcomes

  1. platelet aggregation

    Time frame: 5 days

Sponsors and collaborators

Lead sponsor

Kantonsspital Graubünden

Other

Registry information

Important dates

Study start
2006
Study completion
2007
First posted
Sep 27, 2007
Registry last updated
Sep 28, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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