Platelet Inhibition and Bleeding in Patients Undergoing Emergent Cardiac Surgery

The aim of the study is to evaluate if there is an association between platelet inhibition and surgery-related bleeding in patients undergoing emergent cardiac surgery during dual antiplatelet therapy.

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Key information

Conditions

Bleeding Hemorrhage Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

30 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anesthesiology and Intensive Care Medicine, Department of Surgery, Medical University of Graz

Graz, 8036, Austria

About this study

Blood for measuring platelet function is drawn before induction of anesthesia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

First time on-pump CABG with or without valve replacement

Exclusion criteria

Redo surgery,
Renal insufficiency needing dialysis,
Concomitant medication with warfarin,
Preoperative fibrinogen < 150 mg%

Treatment and study plan

Primary outcomes

Calculated Blood Loss

Time frame: until postoperative day 5

Secondary outcomes

BARC Bleeding

Time frame: until postoperative day 2

Intracranial bleed within 48 hours, Reoperation after closure of sternotomy for the purpose of controlling bleeding, Transfusion of equal to or more than 5 Units of packed red blood cells within a 48-hour period, Chest tube output of equal to or more than 2 L within a 24-h period.

Sponsors and collaborators

Lead sponsor

Medical University of Graz

Other

Registry information

Official study title

Does Platelet Inhibition Predict Surgery Related Bleeding in Patients Undergoing Emergent Cardiac Surgery During Dual Antiplatelet Therapy - a Pilot Study

Important dates

Study start: 2011
Primary completion: 2014
Study completion: 2014
First posted: Nov 9, 2011
Registry last updated: Jun 18, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed