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Completed

NCT Number: NCT00976196

Platelet Hyperreactivity Project

The PHP study aims to delineate gene products involved in high on-treatment platelet reactivity in aspirin-treated cardiovascular patients.

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Key information

Conditions

Platelet Reactivity

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Geneva

Geneva, 1205, Switzerland

About this study

The PHP study aims to delineate gene products involved in high on-treatment platelet reactivity in aspirin-treated cardiovascular patients using a system biology approach that include proteomics analysis of selected platelet sub-fractions in patients displaying extreme phenotype.

Main objective:

  • to characterize the proteome profile of platelet hyperreactivity in aspirin-treated cardiovascular patients

Secondary objectives:

  • to characterize the platelet hyperreactivity phenotype in cardiovascular patients treated with aspirin
  • to determine genetic polymorphisms associated with platelet hyperreactivity

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Documented symptomatic ischemic atherothrombotic disease treated by aspirin.

Exclusion criteria

  • Known platelet disorder
  • Chronic treatment by antiplatelet drugs other than aspirin
  • Chronic anticoagulant treatment
  • Chronic non steroidal anti-inflammatory drug treatment
  • Active cancer
  • Treatment with serotonin reuptake inhibitors

Treatment and study plan

Primary outcomes

  1. proteome profile of platelet hyperreactivity

    Time frame: cross sectional

    to characterize the proteome profile of platelet hyperreactivity in aspirin-treated cardiovascular patients

Secondary outcomes

  1. platelet hyperreactivity phenotype in cardiovascular patients treated with aspirin

    Time frame: cross sectional

Other outcomes

  1. genetic polymorphisms associated with platelet hyperreactivity

    Time frame: cross sectional

Sponsors and collaborators

Lead sponsor

Pierre Fontana

Other

Registry information

Official study title

Platelet Hyperreactivity Project: A System Biology Approach of High On-treatment Platelet Reactivity in Aspirin-treated Cardiovascular Patients

Acronym: PHP

Important dates

Study start
2009
Primary completion
2010
Study completion
2010
First posted
Sep 14, 2009
Registry last updated
Dec 2, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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