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Completed

NCT Number: NCT03355625

Platelet Function During Extracorporeal Membrane Oxygenation in Adult Patients

The primary aim is to describe platelet function in adult patients treated with extracorporeal membrane oxygenation (ECMO). A clarification of the platelet function in these critically ill patients contributes to an understanding of the mechanisms underlying their coagulopathy.

The present study is a substudy to the study entitled; "Coagulopathy During Extracorporeal Membrane Oxygenation" (pending Clinical Trial ID number).

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Key information

Conditions

Extracorporeal Membrane Oxygenation Blood Platelets Intensive Care Units Platelet Activation Platelet Aggregation Platelet Function Tests

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre of Haemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark

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About this study

The knowledge of platelet function during extracorporeal membrane oxygenation (ECMO) remains sparse. In the present study, the aim is to investigate platelet function in adult patients treated with ECMO using flow cytometry. The investigators hypothesize that platelet function increases from day 1 to day 3 in patients treated with ECMO. The secondary aim is to investigate the association between platelet function and the incidence of bleeding episodes and thrombosis during ECMO treatment.

The present study is a substudy to the study entitled; "Coagulopathy During Extracorporeal Membrane Oxygenation" (pending Clinical Trial ID number).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Treatment with veno-venous or veno-arterial ECMO
  • Age ≥18 years

Exclusion criteria

  • ECMO treatment initiated post-operatively

Treatment and study plan

Primary outcomes

  1. Changes in platelet function

    Time frame: Platelet function measured day 1 and day 3 on ECMO

    Platelet function on day 3 compared with day 1 on ECMO. Measured by flow cytometry

Secondary outcomes

  1. Changes in platelet aggregation

    Time frame: Platelet function measured every morning from day 1 to day 8 on ECMO (except weekends).

    Comparison of platelet aggregation measured by whole blood impedance aggregometry (Multiplate).

  2. Immature platelet count

    Time frame: Measured every morning from day 1 to day 8 on ECMO (except weekends)

    Estimation of platelet turn-over measured by a blood analyzer (Sysmex)

  3. Platelet count

    Time frame: Measured every morning from day 1 to day 8 on ECMO (except weekends)

    Estimation of platelet count measured by a blood analyzer (Sysmex)

Sponsors and collaborators

Lead sponsor

Aarhus University Hospital

Other

Collaborators

  • University of Aarhus

Registry information

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Nov 28, 2017
Registry last updated
May 26, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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