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Completed

NCT Number: NCT03733912

Plasticizers and in Vitro Fertilization Outcomes

To investigate the effect of Plasticizer metabolites concentration on the in vitro fertilization outcomes

Completed

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Key information

Conditions

Fertilization in Vitro

Age range

30 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

Kaohsiung Veterans General Hospital

Kaohsiung City, 81362, Taiwan

About this study

This study was conducted in a medical center in southern Taiwan. 80 infertile female patients, aged 30 to 40 years old with normal ovarian function, receiving IVF treatment in the infertility outpatient were enrolled in this study. The participates were divided into two groups: successful pregnancy in the IVF cycle (n = 40) and non-pregnancy in the IVF cycle (n = 40). After getting the consent of the patients, we plan to do a questionnaire survey. Additionally, environmental dust and urine were sampled and analyzed the concentration of plasticizers metabolites.The aim of this study is to investigate the effect of Plasticizer metabolites concentration on the in vitro fertilization outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Infertile women undergoing in vitro fertilization cycles
  • Normal ovarian reserve (AMH > 1.0 and AFC ≧ 5)

Exclusion criteria

  • Daily homestay time > 12 hrs
  • Diminished ovarian reserve (AMH ≦ 1.0 or AFC<5)
  • Oophorectomy
  • Gynecologic cancer patients
  • Severe male infertility

Treatment and study plan

Phthalate metabolites measurement

Other

To measure phthalate metabolites of urine and house dust in Pregnancy and Non-pregnancy groups

Other names: diethylhexyl phthalate

Primary outcomes

  1. Phthalate of urine

    Time frame: through study completion, an average of 1 year

    Phthalate metabolites concentrations

Secondary outcomes

  1. Phthalate of environmental dust

    Time frame: through study completion, an average of 1 year

    Phthalate metabolites concentrations

Sponsors and collaborators

Lead sponsor

Kaohsiung Veterans General Hospital.

Other

Registry information

Official study title

To Investigate the Effect of Plasticizers on the Pregnancy in Vitro Fertilization Cycles

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Nov 7, 2018
Registry last updated
Feb 18, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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