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Completed

NCT Number: NCT01878916

Plasma Vitamin and Homocysteine Levels and Thrombosis in Patients With Ph-negative MPNs

Hyperhomocysteinemia is a risk for thrombosis. Thrombosis is more frequent in myeloproliferative neoplasms (MPNs) than the normal population. In this study, we investigated the thrombosis incidence, the effects of plasma homocysteine levels on thrombosis, and the correlations between folate, cobalamin, pyridoxine and homocysteine levels in MPNs, and to compare these results with the healthy controls.

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Key information

Conditions

Thrombosis Cardiovascular Diseases Embolism and Thrombosis Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Istanbul University Cerrahpasa Medical Faculty

Istanbul, Turkey (Türkiye)

About this study

Thirty-one new or formerly diagnosed MPN patients who consecutively visitted our outpatient clinic, as well as 40 age and sex matched healthy controls were enrolled in this study.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult MPN patients and healthy controls who gave a written consent were included in the study.

Exclusion criteria

Exclusion criteria

included not giving a written consent and using medications without an indication which may have an effect on plasma homocysteine and vitamin levels.

Treatment and study plan

Primary outcomes

  1. Thrombosis

    Time frame: at least 1 year

Secondary outcomes

  1. High Hcy level

    Time frame: 1 year

Other outcomes

  1. Death

    Time frame: 1 year

Sponsors and collaborators

Lead sponsor

Istanbul University

Other

Registry information

Official study title

Plasma Cobalamin, Folate, Pyridoxine and Homocysteine Levels and Thrombosis in Patients With Philadelphia-chromosome-negative Myeloproliferative Neoplasms

Important dates

Study start
2003
Primary completion
2004
Study completion
2004
First posted
Jun 17, 2013
Registry last updated
Jun 17, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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