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Completed

NCT Number: NCT03899389

Plasma TMAO (Trimethylamine N-oxide) as a Predictive Marker in Coronary Disease Patients

The primary aim of the current research project is to determine whether the TMAO concentration in the blood can serve as a prognostic indicator of myocardial infarction.

The hypothesis is that in patients with recent myocardial infarction, TMAO concentration in blood is higher than in patients undergoing scheduled coronarography.

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Key information

Conditions

Coronary Disease Cardiovascular Diseases Heart Diseases Myocardial Ischemia Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Physical Education and Sport

Gdansk, Pomeranian Voivodeship, 80-336, Poland

About this study

To the study will be included volunteers - patients with stable angina (SA), who were scheduled for conventional coronary angiography, and patients with acute coronary syndrome (ACS) who were admitted to the hospital with chest pain and undergoing coronography surgery. Blood samples will be taken from volunteers once - before the coronography surgery by qualified medical personnel.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosed stable angina (SA) or acute coronary syndrome (ACS) and planned coronography

Exclusion criteria

  • unconscious patient

Treatment and study plan

plasma samples collection

Diagnostic Test

Trimethylamine N-oxide (TMAO) concentration will be determined in plasma samples

Primary outcomes

  1. Trimethylamine-N-oxidec(TMAO) blood concentration

    Time frame: Immediately before coronography.

    TMAO concentration determined by the ultra-performance liquid-chromatography tandem mass spektrometry (UPLC-MS/MS).

Sponsors and collaborators

Lead sponsor

Gdansk University of Physical Education and Sport

Other

Registry information

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Apr 2, 2019
Registry last updated
Apr 4, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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