Skip to main content
OpenTrials
Completed

NCT Number: NCT01544231

Plasma Neutrophil Gelatinase Associated Lipocalin Levels During Emergency Management of Rhabdomyolysis

This research project consists of a prospective diagnostic study conducted on patients with clinical suspicion of rhabdomyolysis admitted to the emergency rooms of the University Hospitals of Nimes, Montpellier, Paris, Nice and Toulon Inter Army Hospital. The main objective of this study is to determine whether the plasma level of Neutrophil Gelatinase Associated Lipocalin (NGAL) may be retained as a predictor of acute renal failure (ARF) occurring within 48 hours after admission for rhabdomyolysis.

Completed

Looking for future studies?

Notify Me

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de Nîmes - Hôpital Universitaire Carémeau, Nîmes, Gard, France

Loading trial locations.

About this study

The secondary objectives of this are:

  • to study plasma NGAL levels on admission to the emergency ward as a marker of morbidity and mortality by considering the following factors: duration of hospitalization, need for extracorporeal blood purification, ICU admission, death.
  • to study the delay between the onset of the proposed cause of rhabdomyolysis and treatment initiation
  • to study the delay between treatment initiation and the occurrence of ARF.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The patient must have given his/her informed and signed consent
  • The patient must be insured or beneficiary of a health insurance plan
  • Patient hospitalized with Creatine Phospho-Kinase > 1000 UI/l

Exclusion criteria

  • The patient is participating in another study
  • The patient is in an exclusion period determined by a previous study
  • The patient is under judicial protection, under tutorship or curatorship
  • The patient refuses to sign the consent
  • It is impossible to correctly inform the patient
  • The patient is pregnant, parturient, or breastfeeding
  • Chronic renal insufficiency with dialysis
  • The patient has an acute coronary syndrome
  • Nephrotoxic medications within 72 hours prior to admission
  • Need for a procedure involving the injection of iodine
  • Patient in shock
  • Occurrence of acute renal failure can be explained by a cause other than rhabdomyolysis.

Treatment and study plan

Plasma NGAL level

Biological

The plasmatic level of Neutrophil Gelatinase Associated Lipocalin is measured in ng/ml/

Primary outcomes

  1. Plasma NGAL level

    Time frame: Admittance to the ermergency room (ie at baseline)

    ng/ml

Secondary outcomes

  1. Delay between initiation of treatment and beginning of acute renal failure

    Time frame: Day 2

    meaured in hours

  2. Delay between cause and treatment

    Time frame: Day 2

    Hours elapsed between proposed cause of rhabdomyolysis and treatment initiation measured in hours.

  3. Need for extracorporeal blood purification

    Time frame: Hospital discharge (expected average of 2-3 days)

    yes/no

  4. Patient admitted to ICU?

    Time frame: Hospital discharge (expected average of 2-3 days)

    yes/no

  5. Length of hospitalization

    Time frame: Hospital discharge (expected average of 2-3 days)

    measured in days

  6. Patient deceased during hospitalization

    Time frame: Hospital discharge (expected average of 2-3 days)

    yes/no

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nīmes

Other

Registry information

Official study title

Plasma Neutrophil Gelatinase Associated Lipocalin (NGAL) Levels During Emergency Management of Rhabdomyolysis: Predicting Renal Failure

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Mar 5, 2012
Registry last updated
Nov 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.