Plasma Brain Natriuretic Peptide Levels in Pregnancy

To evaluate the maternal blood concentrations of brain natriuretic peptide (BNP) during the second and third trimesters of a normal pregnancy. We will attempt to define a normal range for pregnancy and any outliers that may serve as markers for abnormal cardiovascular physiology.

Completed

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Key information

Conditions

Cardiomyopathy Cardiomyopathies Cardiovascular Diseases Heart Diseases Pregnancy

Age range

18 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

Oklahoma State University Center for Health Sciences

Tulsa, Oklahoma, 74127, United States

About this study

The brain natriuretic peptide (BNP) is a useful marker for volume overload, increased filling pressures and stretching of the myocardium. The current literature contains limited and unreliable information regarding normal BNP values in pregnancy. After baseline echocardiogram to detect individuals with asymptomatic structural defects, the participants will submit to 3 blood draws during the second and third trimester and at delivery to determine normal pregnancy values.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

women age 18 to 40
second trimester of pregnancy

Exclusion criteria

known cardiac or valvular disease,
atrial fibrillation or other arrhythmia,
pulmonary hypertension,
chronic hypertension,
hypertensive disorders of pregnancy,
morbid obesity (BMI > 40 kg/meter squared)
history of sleep apnea
multiple gestation
known renal dysfunction
medications known to affect cardiac function
current or past abnormal echocardiogram

Sponsors and collaborators

Lead sponsor

Oklahoma State University Center for Health Sciences

Other

Registry information

Important dates

Study start: 2006
Study completion: 2008
First posted: May 11, 2006
Registry last updated: Oct 5, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed