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NCT Number: NCT05681858

Plaque Burden and Ischemia in MINOCA

The goal of this clinical trial is to assess coronary artery plaque burden, perivascular inflammation and extent of myocardial ischemia in patients presenting with acute myocardial infarction and non-obstructive coronary artery disease. The main question it aims to answer are:

* Identify coronary artery anatomy, plaque burden, composition and high-risk plaque features by CT coronary angiography in MINOCA * Assess presence, extent and severity of myocardial ischemia in MINOCA

Participants will examined by CT coronary angiography and stress [12N] NH3 PET-MR.

Recruiting

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Key information

Conditions

Minoca Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Clinical Science, University of Bergen

Bergen, 5021, Norway

Location status: Recruiting

Location contact

Mai Tone Lønnebakken, MD phd

CONTACT

[email protected]

+47 55972220

Silja Hanseth, MD

SUB_INVESTIGATOR

Terje H Larsen, MD phd

CONTACT

[email protected]

+4755975000

Terje H Larsen, MD phd

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Acute chest pain
  • Elevated troponin
  • Non-obstructive coronary arteries by coronary angiography

Exclusion criteria

  • Obstructive coronary artery disease
  • Contraindications against CT coronary angiography or stress [12N] NH3 PET-MR
  • Not able to give informed consent

Treatment and study plan

CT coronary angiography and [12N] NH3 PET-MR

Diagnostic Test

Advanced coronary artery plaque analysis, myocardial ischemia and coronary flow reserve

Primary outcomes

  1. Plaque burden

    Time frame: 1 week

  2. Myocardial ischemia

    Time frame: 1 week

Sponsors and collaborators

Lead sponsor

University of Bergen

Other

Collaborators

  • Haraldsplass Deaconess Hospital
  • Haukeland University Hospital

Registry information

Official study title

Coronary Artery Plaque, Perivascular Inflammation and Myocardial Ischemia in Patients With Myocardial Infraction and Non-obstructive Coronary Arteries

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Jan 12, 2023
Registry last updated
Dec 4, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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