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NCT Number: NCT03615599

Plant-based Diets and Risk of Cancer in the Adventist Health Study-2

The Adventist Health Study-2 is a long-term study, exploring the links between lifestyle, diet, and disease outcomes among Seventh-day Adventists. More than 96,000 church members from the U.S. and Canada are participating in the current study, AHS-2, conducted by researchers at the Loma Linda University School of Public Health.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Cancer, Breast Breast Diseases Breast Neoplasms Cancer, Colorectal Cancer, Prostate Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Genital Diseases Genital Diseases, Male Genital Neoplasms, Male Intestinal Diseases Intestinal Neoplasms Male Urogenital Diseases Neoplasms Neoplasms by Site Prostatic Diseases Prostatic Neoplasms Rectal Diseases Skin Diseases Skin and Connective Tissue Diseases Urogenital Diseases Urogenital Neoplasms

Age range

30 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Loma Linda University

Loma Linda, California, 92350, United States

About this study

The Adventist Health Study-2 (AHS-2) is a large national cohort of 96,000 Seventh-day Adventists in the U.S. and Canada. The study is searching for associations between diet and risk of common and medium frequency cancers (breast, prostate, colorectal, lung, uterus, pancreas, melanoma of skin). This cohort is unusual in that about half are vegetarian, many eat soy at Asian levels, and many have very low or absent dairy intake while others eat normal amounts of dairy. Thus observations on these people, many of whom have contrasting dietary habits, may provide insights about diet and cancer, so supporting dietary changes that could be readily adopted by many.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Member of a Seventh-day Adventist church >30 years of age Ability to read English Live in the US or Canada

Exclusion criteria

  • Less than 30 years of age
  • Church members who did not complete the baseline questionnaire.
  • Incarcerated or institutionalized people
  • Non-English speakers

Treatment and study plan

Primary outcomes

  1. Incident cases of breast cancer among subjects with documented dietary habits.

    Time frame: Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment.

    Incident cases of breast cancer as found by linkage with state cancer registries will allow calculation of hazard ratios comparing extreme quintiles of dietary intakes. The focus is on meats, soy, and dairy intakes.

Secondary outcomes

  1. Incident cases of prostate cancer among subjects with documented dietary intakes.

    Time frame: Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment.

    Incident cases of prostate cancer as found by linkage with state cancer registries will allow calculation of hazard ratios comparing extreme quintiles of dietary intakes. The focus is on meats, soy, and dairy intakes.

Other outcomes

  1. Incident cases of colorectal cancer among subjects with documented dietary habits.

    Time frame: Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment.

    Incident cases of colorectal cancer as found by linkage with state cancer registries will allow calculation of hazard ratios comparing extreme quintiles of dietary intakes. The focus is on meats, soy, and dairy intakes.

Sponsors and collaborators

Lead sponsor

Loma Linda University

Other

Collaborators

  • Ardmore Institute of Health
  • National Cancer Institute (NCI)
  • World Cancer Research Fund International

Registry information

Official study title

Cancer Epidemiology in Seventh-day Adventists

Acronym: AHS-2

Important dates

Study start
2002
Primary completion
2013
Study completion
2028
First posted
Aug 6, 2018
Registry last updated
Jan 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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