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OpenTrials
Completed

NCT Number: NCT03907059

Plant-based Dietary Protein and Resistance-training Adaptations

Dietary protein consumption maximizes the anabolic response during resistance training (RT) by triggering muscle protein synthesis and providing the indispensable amino acids for a net positive protein balance. Leucine is considered the key amino acid in this process, suggesting that differences in protein quality may influence RT-induced gains in muscle mass and strength. In general, plant-based protein sources have lower leucine concentrations than animal-based protein sources and human skeletal muscle. In this respect, despite acute evidence on lower anabolic properties of plant- vs. animal-based protein, the effects of an exclusive plant-based dietary protein diet on RT-induced adaptations are currently unknown.

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Key information

Conditions

Healthy Hypertrophy Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of Sao Paulo

São Paulo, 05508-030, Brazil

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy young men
  • Vegans ≥ 1 y or omnivorous subjects
  • Physically active but no resistance-trained subjects
  • Without any chronic injury that impairs resistance training performance
  • Protein intake > 0.8 g/protein/kg body weight

Exclusion criteria

  • Use of creatine or beta-alanine supplements for the last 3 months
  • Use of proteins and/or amino acids supplements for the last 1 month
  • Engagement in specific dietary restrictions
  • Previous use of anabolic steroids
  • Engagement in any training program

Treatment and study plan

Whey Protein

Dietary Supplement

supplementation individually adjusted to 1.6g/kg/day

Soy protein

Dietary Supplement

supplementation individually adjusted to 1.6g/kg/day

Primary outcomes

  1. Muscle cross-sectional area

    Time frame: 12 weeks

    assessed by mode-B ultrasound

  2. Muscle strength

    Time frame: 12 weeks

    assessed by leg-press one-maximum-repetition

Secondary outcomes

  1. Leg lean mass

    Time frame: 12 weeks

    assessed by Dual-energy X-ray absorptiometry

  2. fiber cross-sectional area

    Time frame: 12 weeks

    assessed by muscle biopsy (vastus lateralis)

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Registry information

Official study title

Does Exclusive Consumption of Plant-based Dietary Protein Impair Resistance Training-induced Muscle Adaptations?

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Apr 8, 2019
Registry last updated
Apr 9, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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