Plan to Evaluate Early Endothelialization of a Polymer Free Sirolimus-eluting Coronary Stent System (VIVO ISARTM) Compared With Everolimus-eluting Durable Polymer Stent (XIENCE SkypointTM) in Patients Undergoing Percutaneous Coronary Intervention.

To evaluate the stent endothelialization (> 20 microns) of VIVO ISARTM versus XIENCE SkypointTM stents at 1-month (very early strut covered) at follow-up by Optical Coherence Tomography (OCT) implanted IN THE SAME PATIENT during routine clinical practice.

Inclusion criteria

• Patients with age ≥ 18 years AND
• Patients who have signed informed consent AND
• Patients with coronary artery disease requiring percutaneous treatment with coronary stents due to de novo lesions in vessels with a diameter of reference from 2.25 mm to 4.0 mm AND
• Patients with at least 2 angiographic lesions in 2 different major coronary arteries. Or in the main branch and in one of its subsidiaries branches , as long as those are not "downstream" of the lesion from the main branch

Exclusion criteria

• Express refusal of the patient to participate in the study
• Patients with ST elevation Myocardial Infarction or Cardiogenic Shock
• Patients with high thrombotic content
• Pregnant or breastfeeding patients
• Patients with complex PCI (Percutaneous Coronary Intervention )(defined as):

• Left main PC
• Chronic total PC occlusion
• Bifurcation lesion requiring 2-stent technique .
• Severe calcified lesion (need to use prior complex techniques of calcium modification such as intravascular lithotripsy, rotational/orbital atherectomy, laser.
• Patients with malignant neoplasms or other comorbid conditions with life expectancy <12 months
• Patients with a target lesion in a bypass graft
• Lesions due to restenosis
• Patients with PCI in the target vessel in the previous 9 months
• Patients with contraindication or difficulty to evaluate in the follow-up with OCT (renal failure, excessive tortuosity or lesions aorto-ostial)