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NCT Number: NCT07144839

Placental Risk Assessment to CusTomize Individualized Pregnancy Care and Evaluation

This is a prospective observational study with the goal of developing and assessing a predictive model of placental insufficiency.

Recruiting

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Key information

Conditions

Stillbirth Death Female Urogenital Diseases and Pregnancy Complications Fetal Death Pathologic Processes Pathological Conditions, Signs and Symptoms Placenta Diseases Placental Insufficiency Pregnancy Complications Urogenital Diseases

Age range

15 year–50 year

Sex eligibility

Female

Study type

Observational

Primary location

Oregon Health & Science University

Portland, Oregon, 97239, United States

Location status: Recruiting

Location contact

Women's Health Research Unit

CONTACT

[email protected]

503-494-3666

About this study

Pregnant study participants will be recruited and monitored throughout pregnancy with ultrasound and blood draws, and delivery and neonatal data up to 28 days following birth. This data will be used to develop a model to predict placental insufficiency.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pregnant
  • Age 15 or older
  • No known major fetal anatomic or genetic abnormalities
  • Singleton gestation
  • Planning to deliver at Oregon Health & Science University
  • Prior to 22 weeks' gestation

Exclusion criteria

  • Decisional impairment
  • Multiple gestation
  • Known fetal growth restriction or major congenital anomaly
  • Inability to consent
  • Inability to attend study visits

Treatment and study plan

Data Collection Throughout Pregnancy and Delivery

Other

Participants will receive monitoring by ultrasound and blood tests at three time points during pregnancy, and delivery and neonatal data will be collected.

Primary outcomes

  1. Number of participants with placental insufficiency composite

    Time frame: At time of delivery to 28 days following delivery

    The composite is made of the following: stillbirth and neonatal death, severe forms of hypertensive disease, placental abruption, birthweight below the 3rd percentile, umbilical cord arterial pH<7, and/or placental primary indication for delivery (FGR, oligohydramnios, abnormal fetal testing)

Study contacts

Contact information is provided by the study sponsor or research team.

Women's Health Research Unit Department of Ob/Gyn

CONTACT

[email protected]

503-494-3666

Sponsors and collaborators

Lead sponsor

Oregon Health and Science University

Other

Collaborators

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Registry information

Official study title

Clinical Utility of a Predictive Model of Placental Insufficiency

Acronym: PRACTICE

Important dates

Study start
2025
Primary completion
2029
Study completion
2029
First posted
Aug 28, 2025
Registry last updated
Dec 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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