PJ-011726 IntelliSpace Cognition MCI Study

Inclusion criteria

• Aged 50-80
• Patient is able to give consent
• MCI or amnestic MCI diagnosis by a clinical specialist, such as a neurologist - diagnosis not older than 12 months prior to inclusions date.
• If 3D T1 MRI images are present they cannot be older than 6 months prior to the MCI clinical diagnosis was made.
• Must be proficient in American English.
• If patient has vision impairment or hearing loss, must be corrected to normal.
• Must have use of fingers, hands, and arms to be able to use a pencil to write symbols.
• Must be able to understand test instructions and participate fully in testing.

Exclusion criteria

• Currently admitted to a hospital, assisted living, nursing home or a psychiatric facility.
• Diagnosed with a (neurological) disorder other than MCI or aMCI, i.e.:

• Current primary neurodegenerative diseases (e.g., Parkinson's disease, brain tumor, dementia)
• Stroke
• Current TBI
• Current epilepsy [if # seizures ≤ 2 and not receiving ongoing treatment for seizures, and not currently seeking medical evaluation or attention related to seizures, patient can be accepted],
• Current encephalitis
• Current language disorder (expressive or mixed receptive/expressive excluded; articulation disorder is ok)
• Current learning disorder
• Current or past psychotic disorder
• Current severe mood disorder (in the case of Major Depressive Disorder in remission or with no current episode, and Dysthymic and Adjustment disorder, examinee can be accepted)
• Current severe anxiety disorder (e.g., PTSD, GAD, OCD) with symptoms significant enough to interfere with optimal test performance (in the case of phobias, examinee can be accepted)
• Current or past Autism Spectrum Disorder or Intellectual Disability
• Primarily nonverbal or uncommunicative
• Current aphasia
• LUPUS
• Multiple Sclerosis
• Sleep apnea (moderate or severe, Apnea-Hypopnea Index <15 is acceptable)
• Major structural intracranial abnormalities and brain disorders on prior imaging study (in the last 12 months), i.e.:

• Major developmental disorders (e.g., polymicrogyria, schizencephaly)
• Intracranial tumors: intraaxial (brain tumors); extraaxial (tumors of bone and meninges) insofar they exert mass effect on the brain with edema or gliosis
• Chronic brain injury and acquired focal or diffuse loss of normal parenchyma regardless of the etiology (e.g. prior stroke,brain surgery, trauma, atrophy due to neurodegenerative disease such as frontotemporal degeneration; or other causes), with the exception of age related changes (e.g. mild-moderate cerebral volume loss) on either side and prior surgery that involved only the skull but not the brain
• Vascular encephalopathy, defined as Fazekas grade 2 or lower
• Any history of having been unconscious related to TBI or "medical condition" > 20 minutes or have had any head-injury resulting in an overnight hospital stay
• Any history of a medical event requiring resuscitation in which examinee was non-responsive for > 15 minutes
• Currently receiving chemotherapy treatment, or have received chemotherapy treatment in the past 2 months
• Any history of ECT or radiation to the CNS
• Currently diagnosed with substance abuse or dependence, or have carried any substance abuse or dependence diagnosis in the past year (> 1 year in remission diagnoses are ok)
• A current average alcohol consumption of 4 or more units per day. Long term alcohol abusers are excluded as well (e.g., abused substance for more than 10 years)
• Currently taking medication that might impact test performance (i.e. anti- convulsants, antipsychotics, benzodiazepines, psychostimulants, opioids, tricyclic Antidepressants, Oxybutynin)
• Disruptive behavior or insufficient compliance with testing to ensure a valid assessment
• Non-valid health insurance in USA