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NCT Number: NCT03707691

Pitch Perception and Memory: Deficits and Training

Pitch perception and memory are central in auditory cognition, in particular for sound source segregation and recognition, speech prosody and music processing. Here the investigator assess pitch perception and memory in hearing-impaired listeners wearing cochlear implant(s) and listeners with congenital amusia, both compared with control listeners. Behavioral, EEG, and MEG measures are collected in audio and audio-visual contexts to characterize pitch processing deficits, and test a pitch training program.

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Key information

Age range

5 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Lyon Neuroscience Research Center

Bron, 69500, France

Location status: Recruiting

Location contact

Anne CACLIN, PhD

CONTACT

[email protected]

4 72 13 89 04 ext. +33

Anne CACLIN, PhD

PRINCIPAL_INVESTIGATOR

Annie MOULIN, PhD

SUB_INVESTIGATOR

Aurélie BIDET-CAULET, PhD

SUB_INVESTIGATOR

Barbara Tillmann, PhD

CONTACT

[email protected]

4 37 28 74 89 ext. +33

Barbara Tillmann, PhD

SUB_INVESTIGATOR

Eric TRUY, MD, PhD

SUB_INVESTIGATOR

Ruben HERMANN, MD

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For adult participants:

  • Aged between 18 and 90
  • Absence of neurological and psychiatric disorders
  • No major cognitive deficit, ability to understand and apply study instructions
  • Motivation to participate efficiently in the study
  • Written informed consent to participant in the study
  • Affiliated to social security
  • Control participants and participants with congenital amusia for Experiment 5: MRI/MEG compatibility

For underage participants:

  • Subject aged 5 years and over
  • Informed consent of parents or guardians for the participation of the child being studied
  • No neurological or psychiatric history
  • Without major cognitive impairment and ability to understand and apply setpoint.
  • Subject affiliated to a social security scheme
  • Motivation to participate effectively in the project

Exclusion criteria

For adult participants:

  • Age below 18 or above 90
  • Pregnant or breast-feeding woman

For underage participants:

  • Pregnant or nursing minors

Treatment and study plan

Listening tests. Pitch training protocol

Behavioral

The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of ~20 minutes performed at home over a period of 15 weeks.

visuo-spatial training protocol

Behavioral

The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of ~20 minutes performed at home over a period of 15 weeks.

EEG/MEG/MRI recordings.

Behavioral

Listening tests. EEG/MEG/MRI recordings

Primary outcomes

  1. percentages of correct responses in listening tests

    Time frame: during procedure

  2. reaction times in listening tests

    Time frame: during procedure

  3. Event-Related Fields

    Time frame: during procedure

    MEG measurements

  4. Oscillations

    Time frame: during procedure

    MEG measurements

Secondary outcomes

  1. percentages of correct responses

    Time frame: Day 0

    Performance in listening tests in audio contexts

  2. percentages of correct responses

    Time frame: Day 0

    Performance in listening tests in audio-visual contexts

  3. reaction times

    Time frame: Day 0

    Performance in listening tests in audio contexts

  4. reaction times

    Time frame: Day 0

    Performance in listening tests in audio-visual contexts

  5. Event-Related Fields

    Time frame: Day 0

    EEG measurements

  6. Oscillations

    Time frame: Day 0

    EEG measurements

Study contacts

Contact information is provided by the study sponsor or research team.

Anne CACLIN

CONTACT

[email protected]

4 72 13 89 04 ext. +33

Barbara Tillmann

CONTACT

[email protected]

4 37 28 74 89 ext. +33

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Acronym: Pitch_Train

Important dates

Study start
2019
Primary completion
2027
Study completion
2027
First posted
Oct 16, 2018
Registry last updated
Mar 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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