Skip to main content
OpenTrials
Completed

NCT Number: NCT01821820

Pistachios, Performance, Metabolomics

Ingestion of 3 ounces of pistachio nuts per day for two weeks before and the day of cycling intensely for 75 kilometers will support substrate utilization during exercise (as determined through metabolomics) and improve performance compared to water only, and attenuate inflammation, oxidative stress, and immune dysfunction during 24 hours of recovery.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Inflammation Immune Dysfunction Immune System Diseases Oxidative Stress Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–55 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

ASU Human Performance Laboratory, North Carolina Research Campus

Kannapolis, North Carolina, 28787, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male endurance cyclists
  • Capable of exercising for 2.5 h at a high intensity in the lab
  • Ages 18-55
  • Agree to train normally and stay weight stable.
  • Agree to avoid the use of large dose vitamin/mineral supplements
  • Agree to avoid herbs and medications that influence inflammation

Exclusion criteria

  • Regularly take supplements or medicines known to effect inflammation.
  • At moderate or high risk for cardiovascular disease.
  • Younger than 18 or older than 55 years of age.
  • No history of competing in cycling races.

Treatment and study plan

Pistachios

Other

Primary outcomes

  1. Shifts in metabolites (metabolomics)

    Time frame: 14-day period

    Shifts in metabolites pre-and post-14-days supplementation, and then after 75-km cycling, and the next morning.

Secondary outcomes

  1. Inflammation

    Time frame: 14-day period

    Pre- and post-14 d supplementation, and following 75-km cycling; plasma IL-6, IL-8, IL-10, TNF-alpha, G-CSF, MCP-1; C-reactive protein

  2. Immune Function

    Time frame: 14-day period

    Pre- and post-14 days supplementation, and following 75-km cycling; granulocyte and monocyte phagocytosis and oxidative burst activity; leukoycte differential

  3. Oxidative Stress

    Time frame: 14-day period

    Pre- and post-14 days supplementation, and following 75-km cycling; RBC glutathione, protein carbonyls, ORAC, FRAP, F2-isoprostanes

Sponsors and collaborators

Lead sponsor

Appalachian State University

Other

Collaborators

  • American Pistachio Growers

Registry information

Official study title

Influence of Pistachios on Performance and Exercise-induced Inflammation, Oxidative Stress, and Immune Dysfunction in Athletes: a Metabolomics-based Approach.

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Apr 1, 2013
Registry last updated
Feb 2, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.