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NCT Number: NCT07406100

Piloting the Competence in Romance and Understanding Sexual Health Curriculum

The goal of this clinical trial is to learn whether the CRUSH curriculum is possible (feasible), whether it fits the needs of the adults it is designed for (acceptable), and shows initial signs of being helpful (efficacious). CRUSH is a group-based behavioral intervention plus 1-1 coaching designed to provide sexual education and improve the skills of autistic adults for intimate relationships.

The main goals of the project are to:

* Evaluate the feasibility and acceptability of the CRUSH curriculum in the context of a clinical trial with a waitlist control condition. * Initial exploration of how the CRUSH curriculum works and whether it is helpful.

Participants will complete:

* A screening call. * Confirmation of clinical characteristics (autism features, language ability, cognitive ability). * 3 visits to assess knowledge and behaviors related to dating and sexual health at each point throughout the training curriculum (before beginning, midway, and after finishing). * 20 sessions of the CRUSH curriculum plus 1-1 coaching sessions. After each session, provide feedback about the session.

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Key information

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Boston Children's Hospital, Two Brookline Place

Brookline, Massachusetts, 02445, United States

Location status: Recruiting

Location contact

Susan Faja, PhD

CONTACT

[email protected]

6179194108

About this study

There are currently no evidence-based interventions to improve the dating and sexual health of autistic adults. The CRUSH (Competence in Romance and Understanding Sexual Health) Curriculum was designed to address this critical gap, which was piloted with a small group of participants. This study is a pilot program of the CRUSH curriculum for 40 participants to acquire initial feasibility and acceptability data. It will also test the feasibility and acceptability of the measurement battery for potential inclusion in future clinical trials. The goal of this clinical trial is to learn whether the CRUSH curriculum is possible (feasible), whether it fits the needs of the adults it is designed for (acceptable), how it works (mechanism), and shows initial signs of being helpful (efficacious). CRUSH is a group-based behavioral intervention plus 1-1 coaching designed to provide sexual education and improve the skills of autistic adults for intimate relationships.

The main goals of the project are to:

  • Evaluate the feasibility and acceptability of the CRUSH curriculum in the context of a clinical trial with a waitlist control condition.
  • Initial exploration of how the CRUSH curriculum works and whether it is helpful.

Participants will complete:

  • A screening call.
  • Confirmation of clinical characteristics (autism features, language ability, cognitive ability).
  • 3 visits to assess knowledge and behaviors related to dating and sexual health at each point throughout the training curriculum (before beginning, midway, and after finishing).
  • 20 sessions of the CRUSH curriculum plus 1-1 coaching sessions. After each session, provide feedback about the session.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18;0 to 30;11 years old;
  • Either documentation of a prior diagnosis of autism spectrum disorder or receipt of services based on an autism spectrum diagnosis OR self identification as being autistic / on the autism spectrum and meeting the clinical cut-off on either the Autism Diagnostic Observation Schedule or the Autism Spectrum Quotient;
  • Ability to provide consent for the protocol and understand task demands. The Wechsler Abbreviated Scale of Intelligence, Second Edition (WASI-2) may be used to confirm cognitive level. In prior work, adults with full scale IQ of 70 or above on the WASI-2 typically meet this criterion, but a licensed clinician will review individuals who fall below an IQ of 70 on an individual basis to determine eligibility;
  • Fluent in English.

Exclusion criteria

  • Non-English-speaking participants (less than 50% of speech in English);
  • Known genetic etiology of ASD (e.g., Fragile X);
  • Major mental illness (e.g., bipolar disorder, schizophrenia, or psychosis);
  • Medical conditions that impact sexual function (e.g., pituitary tumor);
  • Significant sensory, motor, or physical conditions that would prevent valid participation in assessments or intervention;
  • Live more than 50 miles from the site in Brookline, MA where intervention and assessment sessions will be offered.
  • Receipt of other sexual health/dating curricula as an adult.

Treatment and study plan

Competence in Romance and Understanding Sexual Health (CRUSH)

Behavioral

Manualized curriculum targeting sexual health and behavior in intimate relationships designed to meet the specific needs of autistic adults

Primary outcomes

  1. Acceptability Rating Scale

    Time frame: Within one day of each intervention session and at the Baseline, Midpoint (10 weeks), and Post-intervention visit (20 weeks)

    This is the primary acceptability outcome. Likert ratings with a 5-pt scale

  2. Sexual Vocabulary Test - Pragmatics Total Score

    Time frame: At the Baseline, Midpoint (10-weeks), and Post-intervention (20-weeks) visits

    This is the primary measure of target engagement. A measure of the ability to provide definitions of sexual health terms to be used as a measure of target engagement - the primary dependent variable measures pragmatic language (e.g., slang) when discussing sexual health terms. Accuracy (knowledge of sexual health terms) is also collected as a secondary variable.

  3. Psychosexual Knowledge Test

    Time frame: At the Baseline, Midpoint (10-weeks), and Post-intervention (20-weeks) visits

    This is the primary clinical outcome measure and assesses changes in the information participants have. This task was adapted for the first RCT of a sexual health curriculum developed for autistic adolescents to assess changes in information. It includes 35 multiple choice and 2 open-ended items that are scored as correct or incorrect.

Secondary outcomes

  1. Feasibility Assessment

    Time frame: Within one day of each intervention session and at the Baseline, Midpoint (10 weeks), and Post-intervention visit (20 weeks)

    Attrition rates; Missing data rates for assessment instruments

Study contacts

Contact information is provided by the study sponsor or research team.

Susan Faja, PhD

CONTACT

[email protected]

6179194108

Sponsors and collaborators

Lead sponsor

Boston Children's Hospital

Other

Registry information

Official study title

A Pilot Investigation of the Competence in Romance and Understanding Sexual Health Curriculum

Acronym: CRUSH

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Feb 12, 2026
Registry last updated
Apr 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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