Pilot Study on the Tolerability of Dietary Dried Plum

Dried plums (Prunus domestica L.) have traditionally been recognized for their health benefits related to conditions such as constipation, irregular menstrual cycles and mouth sores. This dried fruit provides high levels of fiber, vitamins and minerals. Dried plum has also been shown in animal studies to have beneficial effects on bone and can prevent the loss of bone caused by low hormone levels such as occurs after surgical removal of the ovaries. We also have shown that dried plum can prevent the loss of bone associated with aging in mice. Very few therapies for osteoporosis actually reverse bone loss and improve bone strength. The potential therapeutic value of dried plum in men and women with hormone deficiency or age-related osteoporosis is clear.

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Key information

Conditions

Healthy Elderly

Age range

50 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of California San Francisco

San Francisco, California, 94143, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age between 50 yrs and 75 yrs
Nonsmokers
Normal renal and hepatic function

Exclusion criteria

Subjects who must follow a specific diet
Subjects on any daily medications that affect bone health
Subjects too heavy for the DEXA machine (weight limit 300 lbs)
Subjects whose BMD by DEXA indicates osteoporosis
Subjects unwilling to follow the diet specified
Pregnant women
Subjects who are unable to understand the consent form.

Treatment and study plan

dried plum powder

Dietary Supplement

subjects will have 25% of their diet substituted by dried plum powder

Primary outcomes

urinary calcium excretion

Time frame: one month

Secondary outcomes

ability to tolerate the diet

Time frame: one month

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Registry information

Important dates

Study start: 2009
Primary completion: 2010
Study completion: 2010
First posted: Dec 18, 2009
Registry last updated: Mar 2, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed