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Completed

NCT Number: NCT00299143

Pilot Study on Shear-induced Platelet Aggregation in Acute Coronary Syndromes

The purpose of this study is to determine whether shear-induced platelet aggregation is able to discriminate first acute coronary syndrome (ACS) from recurrent ACS

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Key information

Conditions

Angina, Unstable Acute Coronary Syndrome Angina Pectoris Cardiovascular Diseases Chest Pain Heart Diseases Myocardial Ischemia Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Vascular Diseases

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Bichat Hospital

Paris, 75018, France

About this study

Predictive factors of recurrence of ACS are not well determined. Platelet aggregation and leucocyte activation seem to be involved in the pathogenesis. The aim of our study is to compare SIPA, platelet activation and platelet-leucocytes aggregates on the onset of the ACS and 3 months later in 2 groups of patients scheduled for a first episode of ACS or recurrent ACS .

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

over 18 years old. informed consent signed. acute coronary syndrome not associated with co-morbidity as bleeding diathesis or myocardial infarction during the procedure.

clinical symptoms in agreement with myocardial infarction during the preceding 24 hours.

CK OR troponin elevation and one or more of the following criteria: ECG modifications transient ST elevation>1 mm. new inversion of ST <1 mm on 2 contiguous derivations.

Exclusion criteria

Acute coronary syndrome with persistent ST elevation. Angioplasty in emergency before blood sampling. Inflammatory disease or cancer. Coagulation abnormalities. Antiphospholipid syndrome. Treatment by vitamin K antagonist. Severe disease with life expectancy lower than 2 years. One-year follow up impossible.

Treatment and study plan

Primary outcomes

  1. Measurement of platelet aggregation induced by shear rates

    Time frame: Day 1, Month 3

    Using rotational viscometer

Secondary outcomes

  1. Measurement of platelet aggregation induced by ADP (Adenosine 5'-diphosphate)

    Time frame: Day 1, Month 3

    Measured by turbidimetry in the of the agonist, at 37°C in an aggregometer (model 490, Chonolog)

  2. Measurement of P-selectin membrane density

    Time frame: Day 1, Month 3

    By flow cytometry (EPICS Profile, Beckman, Coulter)

  3. Measurement of activated alphaIlbbeta3 membrane density

    Time frame: Day 1, Month 3

    By flow cytometry (EPICS Profile, Beckman, Coulter)

  4. Determination of the number of platelet-leucocyte aggregates in the circulating blood

    Time frame: Day 1, Month 3

    By flow cytometry, using antibodies specific to platelets (CD41), polymorphonuclear cells (CD15) and monocytes labelled with a fluorochrome (FITC)

  5. Measuring Von Willebrand factor

    Time frame: Day 1, Month 3

    Carried out on frozen plasma of all patients

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Registry information

Acronym: REACS

Important dates

Study start
2005
Primary completion
2009
Study completion
2010
First posted
Mar 6, 2006
Registry last updated
Jul 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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