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Completed

NCT Number: NCT01128790

Pilot Study of Remote Ischemic Preconditioning in Heart Failure

The purpose of this study is to determine the effect of remote ischemic preconditioning on exercise capacity in patients with heart failure.

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Key information

Conditions

Heart Failure Behavior Cardiovascular Diseases Heart Diseases Left Ventricular Dysfunction Motor Activity Ventricular Dysfunction Ventricular Dysfunction, Left

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Toronto General Hospital

Toronto, Ontario, M5G 2N2, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • LV ejection fraction <40%
  • NYHA functional class II-IV
  • Non ischemic cardiomyopathy
  • Stable

Exclusion criteria

  • recent cardiovascular hospitalization (within last 4 weeks)
  • ischemic cardiomyopathy
  • diabetes mellitus
  • peripheral neuropathy
  • ventricular assist device
  • contraindications to exercise stress testing

Treatment and study plan

Remote Ischemic Preconditioning

Other

4 cycles x 5 mins upper limb blood pressure cuff inflation 20mmHg above systolic blood pressure

Sham control

Other

4 cycles x 5mins blood pressure cuff inflation to 10mmHg

Primary outcomes

  1. Exercise performance - VO2, exercise time, exercise workload, anaerobic threshold

    Time frame: 1 week

Sponsors and collaborators

Lead sponsor

University Health Network, Toronto

Other

Collaborators

  • The Hospital for Sick Children

Registry information

Official study title

Effect of Remote Ischemic Preconditioning on Exercise Capacity in Patients With Heart Failure: A Double Blind Randomized Control Trial

Important dates

Study start
2009
Primary completion
2011
Study completion
2011
First posted
May 24, 2010
Registry last updated
Dec 23, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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