Pilot Study Of Primary And Secondary Attention-Deficit/Hyperactivity Disorder Among Survivors Of Childhood Cancer

• This study will investigate the feasibility of assessing symptoms of developmental ADHD and "secondary ADHD" (S-ADHD) among adolescent survivors of childhood cancer using a structured diagnostic clinical interview procedure. (S-ADHD describes an acquired clinical presentation that is consistent with the diagnostic criteria of ADHD).
• This study will provide preliminary estimates of the rate of occurrence of ADHD/S-ADHD among adolescent survivors of childhood cancer as compared to the prevalence of developmental ADHD in the general population.
• The study will examine the relationship between ADHD/S-ADHD symptoms and laboratory measures traditionally used to assess specific components of attention (e.g., CPT) in survivors of childhood cancer.
• The study will examine the relationship between ADHD/S-ADHD symptoms and smoking (including intentions, behaviors, and motivators) among adolescent survivors of childhood cancer.

Inclusion criteria

• Patients treated for acute lymphoblastic leukemia (ALL) OR primary central nervous system (CNS) tumor.
• Completed primary treatment at least one year prior to enrollment with no evidence of active disease.
• Age 12-17 years inclusive at the time of enrollment.
• At least one parent/guardian must be present.
• Participant and parent are able to understand English.
• Participant and parent are willing and able to provide consent/assent according to institutional guidelines.
• Parent/guardian signs consent.

Exclusion criteria

1.Significant impairment in intellectual functioning (e.g., full or estimated IQ <70) as documented in the medical record.