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NCT Number: NCT07302503

Pilot Study Evaluating brainQuant's Ability to Detect Alterations in White Matter in Diffusion MRI, Indicative of Post-traumatic Lesions

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease described in boxing, but also in contact sports such as American football.

Soccer, due to repeated headers, could also be associated, albeit to a lesser degree, with the development of this type of pathology.

Indeed, it has been shown that playing soccer can be accompanied by cognitive impairments, and neurodegenerative brain abnormalities have been described in neuropathology studies of former professional soccer players. Subradiological brain abnormalities have been found in multimodal MRI in various sports. Similarly, a decrease in cognitive performance has been described.

The discovery of this type of anomaly in a population of professional footballers nearing the end of their careers could lead to:

* The implementation of appropriate monitoring for professional footballers through early detection of lesions via MRI and cognitive disorders * The implementation of preventative measures for professional footballers, but also for amateur footballers from a very young age.

Recruiting

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Key information

Age range

32 year–60 year

Sex eligibility

Male

Study type

Observational

Primary location

Service d'Imagerie 2 - Réanimation - CHU de Strasbourg - France

Strasbourg, 67091, France

Location status: Recruiting

Location contact

Stéphane KREMER, MD, PhD

PRINCIPAL_INVESTIGATOR

Stéphane KREMER, Stéphane KREMERMD, PhD

CONTACT

[email protected]

33 3 88 12 78 48

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male subject
  • Aged 32 to 60 years inclusive
  • Professional footballer nearing the end of their career or recently retired, or subject who has never regularly participated in sports that expose them to head trauma (particularly rugby, basketball, handball, American football, hockey, combat sports, etc.)

Exclusion criteria

  • Subject who expressed their opposition to participating in the study

Treatment and study plan

Primary outcomes

  1. Changes found in MRI diffusion tensor imaging of professional football players

    Time frame: day 1 post-consultation

Study contacts

Contact information is provided by the study sponsor or research team.

Stéphane KREMER, MD, PhD

CONTACT

[email protected]

33 3 88 12 78 48

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Acronym: BQ TC-foot

Important dates

Study start
2024
Primary completion
2028
Study completion
2028
First posted
Dec 24, 2025
Registry last updated
Dec 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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