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NCT Number: NCT07752563

Pilot RCT of Computer-based Eye Movement Training

The goal of this study is to learn whether NeuroEyeCoach, a computer-based eye movement training programme, can help stroke survivors with visual field loss. The study will also assess whether a larger clinical trial is feasible. The main questions it aims to answer are:

* Can stroke survivors be successfully recruited, randomised and followed up in a larger trial? * Is NeuroEyeCoach acceptable and practical to use? * Is there early evidence that NeuroEyeCoach improves vision-related functioning and wellbeing? Researchers will compare NeuroEyeCoach plus usual care with usual care alone.

Participants will:

* Be randomly assigned to receive NeuroEyeCoach plus usual care or usual care alone * Complete six weeks of training if allocated to NeuroEyeCoach * Complete questionnaires and tests of vision, daily activities, quality of life, confidence and wellbeing * Take part in follow-up assessments over six months This pilot trial will include 60 stroke survivors living with visual field loss after stroke. Findings will be used to inform the design of a larger study.

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult (>18 years)
  • stroke survivor
  • stroke-related homonymous VFL (minimum quadrantanopia)
  • sufficient language, cognitive, and upper limb ability to participate in trial activities.

Exclusion criteria

  • pre-existing (ie pre-stroke) registration as sight impaired (partially sighted) or severely sight impaired (blind)
  • • history of seizure disorders, especially those of a photosensitive nature

Treatment and study plan

NeuroEyeCoach eye movement training

Device

computer based eye movement training for visual field loss in stroke

Usual Care

Other

Usual post-stroke care

Primary outcomes

  1. Recruitment rate

    Time frame: through study completion, estimated at 15 months

    Rate of recruitment to the trial

Secondary outcomes

  1. Retention Rate

    Time frame: through study completion, estimated at 15 months

    Rate of retention of participants in the study

  2. Screening and eligibility rate

    Time frame: Active screening period

    Screening and eligibility rate

  3. Outcome measure completion rate

    Time frame: over data collection period

    through study completion, estimated at 15 months

  4. intervention adherence

    Time frame: 6 weeks

    adherence to recommended training regime (duration)

  5. Adverse events

    Time frame: up to 6 weeks

    any adverse eventa experienced

  6. Support and computer provision needs

    Time frame: up to 6 weeks

    To what extent must technical equipment or assistance be given

  7. NEI VFQ 25 (National Eye Institute Visual Function Questionnaire-25)

    Time frame: baseline, 6 weeks post randomisation, 6 months post randomisation

    Patient-reported measure of vision-related functioning. Minimum value is 0, and maximum value is 100; higher scores mean a better outcome

  8. EQ-5D 5L

    Time frame: baseline, 6 weeks post randomisation, 6 months post randomisation

    Generic health related quality of life Maximum value 1.0; better scores mean a better outcome

  9. IReST (International Reading Speed Test)

    Time frame: baseline, 6 weeks post randomisation, 6 months post randomisation

    Reading test (words per minute)

  10. Melbourne Rapid Fields

    Time frame: baseline, 6 weeks post randomisation, 6 months post randomisation

    visual field test

  11. Confidence after Stroke Measure

    Time frame: baseline, 6 weeks post randomisation, 6 months post randomisation

    Validated questionnaire that explores self-confidence, positive attitude and social confidence Minimum score is 0 and the maximum score is 81; a higher score indicates better outcome Ref: Horne JC, Lincoln NB, Logan PA. Measurement of confidence: the development and psychometric evaluation of a stroke-specific, measure of confidence. Clin Rehabil. 2017 Nov;31(11):1529-1537. doi: 10.1177/0269215517705424. Epub 2017 May 3. PMID: 28466669; PMCID: PMC5652651.

  12. Warwick-Edinburgh Mental Wellbeing Scale

    Time frame: baseline, 6 weeks post randomisation, 6 months post randomisation

    Mental wellbeing questionnaire Minimum raw score is 7 and the maximum raw score is 35; higher score means a better outcome

  13. health care resource use

    Time frame: baseline, 6 weeks post randomisation, 6 months post randomisation

    health care resource use, covering general, stroke specific, and vision specific resources

Study contacts

Contact information is provided by the study sponsor or research team.

Christine Hazelton, PhD

CONTACT

[email protected]

0141 331 8181

Sponsors and collaborators

Lead sponsor

Glasgow Caledonian University

Other

Collaborators

  • National Health Service, United Kingdom

Registry information

Official study title

Computer-based Eye Movement Training for Stroke-related Visual Field Loss: a Pilot Randomised Controlled Trial

Acronym: CRYSTAL

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Aug 7, 2026
Registry last updated
Aug 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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