Pilot Investigation of Dual Energy CT Imaging on an Online Adaptive Radiation Therapy System

This study is being done to see if researchers can find a better way to image a patient's tumor during radiation treatment.

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Key information

Conditions

Genitourinary System Carcinoma Malignant Pelvic Neoplasm Neoplasms Neoplasms by Site Pelvic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

* Patients with pelvis or genitourinary (GU) cancer requiring standard of care radiotherapy treatment

All adults, defined as individuals of 18 years of age or greater
Radiotherapy treatment will be performed on the Varian Ethos radiotherapy system
Ability to understand and the willingness to sign a written informed consent

Exclusion criteria

* Minors, defined as individuals less than 18 years of age

Pregnant or nursing female

Treatment and study plan

Non-Interventional Study

Other

Non-interventional study

Primary outcomes

Image quality- Mean

Time frame: Up to 2 years

The primary analysis will compare imaging quality endpoints processed by DE-CBCT and the standard of care SE-CBCT, with the latter representing the standard clinical acquisition. Descriptive statistics will be computed for the image quality metrics from each imaging modality and for the difference in metrics between the modalities. A paired t-test or Wilcoxon signed-rank test will compare the distribution of the image quality metrics between DE-CBCT and standard of care SE-CBCT. Secondary analysis will compare image quality endpoints between DE-CBCT and standard of care conventional planning CT.
Image quality- median

Time frame: Up to 2 years

The primary analysis will compare imaging quality endpoints processed by DE-CBCT and the standard of care SE-CBCT, with the latter representing the standard clinical acquisition. Descriptive statistics will be computed for the image quality metrics from each imaging modality and for the difference in metrics between the modalities. A paired t-test or Wilcoxon signed-rank test will compare the distribution of the image quality metrics between DE-CBCT and standard of care SE-CBCT. Secondary analysis will compare image quality endpoints between DE-CBCT and standard of care conventional planning CT.

Sponsors and collaborators

Lead sponsor

University of Michigan Rogel Cancer Center

Other

Collaborators

Varian Medical Systems, Inc.

Registry information

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Oct 21, 2025
Registry last updated: Apr 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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