Pilot Feasibility of Rice Bran Supplementation in Nicaraguan Children

Rice bran is a globally accessible, underutilized food ingredient with an array of beneficial nutrients (e.g. phytochemicals and prebiotics) that promote health and potentially prevent diseases. The investigators will determine if dietary rice bran intake can modulate the infant gut microbiome and metabolome to promote gut immunity for the benefit of preventing diarrheal diseases that increase risk for malnutrition and stunting.

The investigators hope to learn about the feasibility of dietary supplementation of heat-stabilized rice bran in weaning children living in regions with increased susceptibility to diarrhea and malnutrition, and whether or not rice bran consumption can modulate the stool microbiome and metabolome.

Inclusion criteria

• Children between the ages of 4 months and 6 months at beginning of recruitment
• Have received the 3 doses of the rotavirus vaccination (RV5)
• Families willing to feed their infant a daily dose of study-provided heat-stabilized rice bran for 6 months

Exclusion criteria

• Have had a diarrheal episode between 4 and 6 months of age
• Have had a prior hospitalization
• Have had an antibiotic or prophylactic treatment within 1 month prior to participation
• Have an ongoing illness, a known immunocompromising condition, or use of medications