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Completed

NCT Number: NCT02942108

Piezoelectric Vibrations and Tissue, Cellular and Molecular Mechanisms of Oral Wound Healing After Third Molar Surgery

The aim of this clinical trial is to investigate and compare the effect of piezoelectric surgery on tissue, cellular and molecular level of oral surgical wound healing and postoperative outcomes (pain, swelling, trismus) after lower third molar surgery in healthy patients

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Key information

Conditions

Tooth, Impacted Stomatognathic Diseases Tooth Diseases

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

School of Dental Medicine, University of Belgrade

Belgrade, 11000, Serbia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • bilaterally symmetrically impacted lower third molars

Exclusion criteria

  • presence of intraoral infection
  • chronic orofacial pain
  • pregnancy/ lactation
  • heavy tobacco smokers
  • alcohol/ drug abuse
  • allergic reaction to medicaments used

Treatment and study plan

piezo surgery

Procedure

conventional surgery

Procedure

Primary outcomes

  1. SOD activity in alveolar bone specimen

    Time frame: immediately after surgery

    Activity of enzyme superoxide dismutase in bone specimens obtained during lower third molar surgery

  2. VEGF levels in alveolar bone specimen

    Time frame: immediately after surgery

  3. MMP-9 level in alveolar bone specimen

    Time frame: immediately after surgery

Sponsors and collaborators

Lead sponsor

University of Belgrade

Other

Registry information

Important dates

Study start
2016
Primary completion
2020
Study completion
2020
First posted
Oct 21, 2016
Registry last updated
Dec 5, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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