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Recruiting

NCT Number: NCT06364514

PICNIC Study - PatIent Centered aNtIbiotic Courses in Children With Medical Complexity

To determine if clinicians can safely reduce antibiotic exposure in children with medical complexity (CMC) who are diagnosed with pneumonia by implementing an intervention that bases total antibiotic duration on an individual's clinical stability.

Recruiting

Interested in participating?

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Key information

Conditions

Pneumonia Infections Lung Diseases Respiratory Tract Diseases Respiratory Tract Infections

Age range

2 year–25 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Boston Children's Hospital

Boston, Massachusetts, 02115, United States

Location status: Recruiting

Location contact

Kathleen D Snow, MD, MPH

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Admitted to the Complex Care Service at Boston Children's Hospital with a provider diagnosis of pneumonia
  • Started on antibiotics by the provider team
  • Ages 2-25 years old

Exclusion criteria

  • Patients initially admitted to the intermediate care unit or ICU due to increased respiratory support needs

Treatment and study plan

Clinical Stability Assessment

Other

Base total days of antibiotics on clinical stability vs utilizing predetermined total days of antibiotics

Primary outcomes

  1. Proportion of eligible patients who consent to participate in the intervention

    Time frame: 48 hours

    Caregiver and medical provider acceptability

  2. Rate of persistent and worsening respiratory symptoms measured by patient's clinical status; the rate of emergency department revisit or hospital readmission within 1 week of antibiotic discontinuation

    Time frame: 1 week

    Patient Safety Outcomes

Secondary outcomes

  1. Median days of antibiotics received for patients in the intervention group as well as from historical control group

    Time frame: 30 days

    Pneumonia antibiotic duration

Study contacts

Contact information is provided by the study sponsor or research team.

Kathleen Snow, MD

CONTACT

[email protected]

6178238926

Sponsors and collaborators

Lead sponsor

Boston Children's Hospital

Other

Registry information

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Apr 15, 2024
Registry last updated
Nov 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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