Physiological Changes With SPG Stimulation in Migraine Patients

Hypothesis:

Stimulation of the SPG at low frequencies (20 Hz)is believed to cause a physiological parasympathetic upregulation which increases VMCA, concentration and cephalic vessel diameter.

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Key information

Conditions

Chronic Migraine

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Danish Headache Center

Copenhagen, Glostrup, 2600, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Chronic migraine patients

Exclusion criteria

Treatment and study plan

Neurostimulation

Device

Neurostimulation of sphenopalatine ganglion (SPG) of 20 Hz

Sham stimulation

Device

Sham stimulation of sphenopalatine ganglion (SPG) with amplitude=0

Primary outcomes

Changes of mean blood velocity of middle cerebral artery (VMCA) using transcranial Doppler upon low frequency SPG stimulation

Time frame: 0-90 min

Sponsors and collaborators

Lead sponsor

Danish Headache Center

Other

Registry information

Official study title

Physiological Changes Induced With SPG Stimulation in Migraine Patients - Amendment to the Pathway M-1 Trial

Important dates

Study start: 2015
Primary completion: 2016
Study completion: 2016
First posted: Jul 29, 2015
Registry last updated: Aug 2, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed