Physiological Brain Atlas Development | Clinical Trial

Key information

Conditions

Parkinson Disease Anxiety Disorders Basal Ganglia Diseases Behavior Behavioral Symptoms Brain Diseases Central Nervous System Diseases Depression Dyskinesias Dystonia Mental Disorders Movement Disorders Nervous System Diseases Neurodegenerative Diseases Neurologic Manifestations Obsessive Compulsive Disorder Obsessive-Compulsive Disorder Parkinsonian Disorders Pathological Conditions, Signs and Symptoms Signs and Symptoms Synucleinopathies Tremor Tremors

Age range

7 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Ohio Sate University

Columbus, Ohio, 43210, United States

About this study

The study proposes the enrollment of candidates undergoing a deep brain stimulator (DBS) implant. Data will be collected before, during and after surgery and will be electronically entered into the Atlas database where it will be stored indefinitely.

The purpose of the study is to create an Atlas to store physiological information utilizing non-rigid MRI normalization algorithms. In addition to collating and analyzing the physiological atlas in a statistical manner that allows the surgeon to predict optimal targeting locations for DBS implants based on multiple physiological variables, including pre-operative severity of disease, intraoperative neurophysiological observations, and post-operative response to DBS stimulation therapy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Any patient between the age of 7-90
Patients who have undergone deep brain stimulation (DBS) surgery as standard of care at The Ohio State University

Exclusion criteria

None

Treatment and study plan

No intervention

Other

No intervention

Other names: Single Arm Group

Primary outcomes

optimal DBS target location

Time frame: intra-operative identification

To create an atlas that will allow physiological information to be assigned to anatomical locations in MRI space, utilizing non-rigid MRI normalization algorithms.

Sponsors and collaborators

Lead sponsor

Ohio State University

Other

Registry information

Important dates

Study start: 2010
Primary completion: 2021
Study completion: 2021
First posted: Sep 28, 2010
Registry last updated: Feb 13, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed