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OpenTrials
Completed

NCT Number: NCT03743610

Physiological Adaptations to Simulated Intermittent Altitude on Human Health and Performance

The investigators expect to find that different intensity and altitude exposure levels will show what kind of intermittent exposure protocol is more beneficial to athletes and healthy individuals that experience acute exposure to altitude during exercise. This may furthermore be related to acute altitude exposure for recreational exercise use as well.

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Key information

Conditions

Altitude Hypoxia Altitude Sickness Respiration Disorders Respiratory Tract Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-70 years of age,
  • history of good health,
  • generally active to competitive athletes.

Exclusion criteria

  • History of cardiac or pulmonary disease,
  • not currently active,
  • unable to exercise or meet study requirements (e.g., number of sessions),
  • live at altitude (>2,100m or 7,000ft).

Treatment and study plan

Simulated altitude

Other

Participants will exercise in simulated altitude will range between 2100 feet and 16400 feet and will increase according to arm guidelines

Placebo simulated altitude

Other

Participants will exercise at sea level at similar percentage of intensities to the simulated altitude group.

Primary outcomes

  1. Change in hemoglobin

    Time frame: Baseline, 2-week, 4-week, 6-week, and 8-week

  2. Change in hematocrit

    Time frame: Baseline, 2-week, 4-week, 6-week, and 8-week

  3. Change in erythropoietin

    Time frame: Baseline, 2-week, 4-week, 6-week, and 8-week

Secondary outcomes

  1. Change in peak VO2

    Time frame: Baseline and 6- and 8-week

    Change from maximal exercise test performed at sea level

  2. Change in cycling performance at altitude

    Time frame: Baseline and 6- and 8-week

    change in aerobic/anaerobic cycling performance at altitude

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

Investigation of Physiological Adaptations to Simulated Intermittent Altitude on Human Health and Performance

Important dates

Study start
2019
Primary completion
2023
Study completion
2023
First posted
Nov 16, 2018
Registry last updated
Feb 20, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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