Physical Exercise and Mental Wellbeing Rehabilitation for Acute Stress-induced Takotsubo Cardiomyopathy: The PLEASE Study

Acute takotsubo cardiomyopathy is characterised by sudden onset left ventricular dysfunction precipitated by major stress. The researchers have shown that recovery is more protracted than previously appreciated, and is associated with persistent major morbidity and a long-term heart failure phenotype. In the absence of any effective therapeutic options, the researchers propose a mechanistic three-arm pilot feasibility trial of early rehabilitation (standardised physical exercise training or cognitive behavioural therapy) versus current standard of care in patients who suffered a very recent episode of takotsubo cardiomyopathy. The primary end-point will be the restoration of cardiac energetic status assessed by 31P-magnetic resonance spectroscopy and the secondary end-points of cortisol awakening response, global longitudinal strain by echocardiography and the 6-minute walk test. If successful, this has the potential for rapid implementation into a large randomised clinical trial.

Inclusion criteria

• A patient who has recently suffered an episode of takotsubo cardiomyopathy within the last three weeks
• Participant who is willing and able to give informed consent for participation in the study.

Exclusion criteria

• Any patient whose takotsubo cardiomyopathy was triggered by a physical illness that would preclude them for taking part in a physical exercise training program.
• Any patient who is not able or not willing to travel to the cardiovascular research facility for their study visits.
• Any patient who is not able to commit to a 12 week supervised training program.
• Inability to exercise on a cycle ergometer (i.e. use of walking aids or prosthetic limbs).
• Contraindication to magnetic resonance scanning such as an implantable cardiac device.
• Pregnancy