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OpenTrials
Completed

NCT Number: NCT03345251

Physical Endometrial Manipulation and Its Effect on ICSI

Unexplained infertility is clinically diagnosed when there are no apparent or clear factors causing infertility on regular infertility assessment tools . Failure of implantation is a possible factor causing unexplained infertility . Implantation is the main rate limiting step in IVF outcome. Implantation is described at cellular and molecular level by adhesion or fixation of good quality embryo to receptive endometrium within a critical period of time which is called the window of implantation .

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

20 year–35 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Algazeerah

Giza, Egypt

About this study

Testing the effect of Physical manipulation of the endometrium on the quality of the endometrium prior to ICSI cycle and if it increases the success rate

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Infertile female age 20-35 years
  • Previous Failed one ICSI trial
  • normal basal hormonal profile [FSH, LH] 3-10 mIU/ml and 1.8-8.5 mIU/ml respectively, --normal endometrial cavity
  • patent tubes
  • normal Husband semen analysis

Exclusion criteria

  • Ovarian factor of infertility
  • Tubal factor of infertility
  • Endometrial factor of infertility
  • Male factor of infertility

Treatment and study plan

Hydrotubation

Device

Other names: Sonohysterography, Endometrial scratching

Primary outcomes

  1. The number of participants who achieved clinical pregnancy

    Time frame: 6 weeks after embryo transfer

    Describes how many participant will continue pregnancy after positive pregnancy test

Secondary outcomes

  1. The number of participants who achieved ongoing pregnancy and live birth

    Time frame: 9 months after embryo transfer

    Describes who many participant will continue pregnancy till he had birth and a live birth

Sponsors and collaborators

Lead sponsor

Aljazeera Hospital

Other

Registry information

Official study title

Physical Endometrial Manipulation and Its Effect on Success Rate in Patients With Previous ICSI Failure

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Nov 17, 2017
Registry last updated
Sep 2, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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