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NCT Number: NCT03947840

Physical Activity and Its Impact on Colon Cancer Surgery

This is a prospective clinical study that studies how the physical activity level before operation of colon cancer affects the outcome of complication and histology.

The hypothesis is that patients who are more physical active have less postoperative complications and different histological immunological response around the tumor.

The investigators are testing the patients before the surgery with physical tests for fitness, strength and physical activity level. Questionnaires are also filled by the patients for pain, anxiety, depression and motivation for life style changes. Their body mass is analyzed with a DEXA (Dual-energy X-ray absorptiometry scan).

For one years the investigators are monitoring their activity and follow up for physical tests, DEXA and questionnaires is at 6 and 12 months.

The histology is analyzed after surgery to se if there is a different immunological response around the tumor.

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Key information

Conditions

Colon Cancer Behavior Colonic Diseases Colonic Neoplasms Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Motor Activity Neoplasms Neoplasms by Site Physical Activity

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Region Vasterbotten, centre of surgery

Umeå, Västerbotten County, 90185, Sweden

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years.
  • Colon cancer which is going to surgery

Exclusion criteria

  • Not able to do physical tests
  • Severe disease that makes a risk to do tests.
  • Not able to make informed consent due to psychic disease or dementia

Treatment and study plan

Physical activity

Behavioral

Se their physical activity level

Primary outcomes

  1. Number of postoperative complications

    Time frame: 1 year

    To study if there are differences in postoperative complications in different active patients.

  2. Rate of immunological response

    Time frame: 1 year

    To study if there is a difference in immunological reaction among physical active patients.

Secondary outcomes

  1. Rate of recovery in physical activity

    Time frame: 1 year

    To study if physical active patients have a faster postoperative recovery

Sponsors and collaborators

Lead sponsor

Umeå University

Other

Collaborators

  • Västerbotten County Council, Sweden

Registry information

Official study title

Physical Activity and Its Impact on Colon Cancer Surgery: Clinical and Histological Effects

Acronym: PACOS

Important dates

Study start
2019
Primary completion
2024
Study completion
2024
First posted
May 13, 2019
Registry last updated
Feb 21, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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