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NCT Number: NCT07700732

Photofunctionalization and Hyaluronic Acid for Posterior Maxillary Implants

This randomized clinical trial evaluates the effect of UV photofunctionalization and hyaluronic acid on dental implants placed in the posterior maxilla. Clinical and radiographic outcomes will be assessed during follow-up

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Tooth Loss Delayed Implant Hyaluronic Acid (HA) Implant Placement Mouth Diseases Periodontal Diseases Stomatognathic Diseases Surface Treatment Tooth Diseases UV Dental Implant

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry Mansoura University

Al Mansurah, Egypt

About this study

The study compares conventional implants, UV-photofunctionalized implants, and UV-photofunctionalized implants with hyaluronic acid application in the posterior maxilla. Implant stability and peri-implant tissue changes will be evaluated clinically and radiographically during follow-up.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with missed single tooth or multiple teeth in posterior maxilla.
  • Patients Free from any para-functional habits.
  • Patient with Adequate inter-arch relation and inter-occlusal space to accommodate the prosthetic restoration.
  • Patient with good oral hygiene.
  • Patients Willing to participate in the study's follow-up intervals.

Exclusion criteria

  • Patients with any local or systemic disease that absolute contraindicate implant placement or surgery.
  • Pregnancy.
  • Patients with any pathological lesion or aggressive periodontal disease at the planned surgical site.
  • Patients on drugs that could affect bone healing process such as bisphosphonate.
  • Heavy Smokers for more than 10 cigarettes a day.
  • Uncooperative patients.

Treatment and study plan

Delayed dental implant placement without photofunctionalization.

Procedure

Delayed dental implants placed without photofunctionalization or hyaluronic acid in the posterior maxilla.

Delayed dental Implant photofunctionalization before placement

Procedure

Delayed dental implants photofunctionalized with UV light before placement in the posterior maxilla.

Delayed dental Implant photofunctionalization and hyaluronic acid application before placement.

Procedure

Delayed dental implants photofunctionalized with UV light and treated with hyaluronic acid before placement in the posterior maxilla.

Primary outcomes

  1. Hard Tissue (peri-implant bone)

    Time frame: - Immediately postoperative - 3 months after implant placement - 9 months after implant placement.

    Marginal bone loss will be assessed using CBCT measured in mm.

  2. Implant Stability

    Time frame: -immediately after implant placement -2 weeks postoperatively -4 weeks postoperatively - 3 months postoperatively - 9 months postoperatively

    Implant stability will be evaluated using Osstell device based on resonance frequency analysis (ISQ values).

Secondary outcomes

  1. Soft Tissue

    Time frame: -After 3 months postoperatively. -After 9 months postoperatively.

    The peri-implant mucosa will be evaluated for signs of inflammation using the Modified Sulcus Bleeding Index (mSBI).

  2. Peri-implant probing depth

    Time frame: After 3 months postoperatively. -After 9 months postoperatively.

    Probing depth will be assessed using a calibrated periodontal probe and measured in mm.

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

Enhancing Implant Success in the Posterior Maxilla: The Impact of Photofunctionalization and Hyaluronic Acid

Acronym: PHOTOHA

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 14, 2026
Registry last updated
Jul 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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