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Completed

NCT Number: NCT02152475

Photodynamic Therapy (PDT) for Oral Disinfection

Photodynamic therapy (PDT) is a technique used for the oral disinfection. In dentistry, PDT for microbial inactivation may reduces both dental plaque and risk of developing caries as well as contributes to treat gingivitis, periodontitis, peri-implantitis and endodontic diseases. The investigators hypothesis was that PDT with blue light and curcumin promotes oral disinfection during 2 hours after treatment.

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Key information

Conditions

Healthy

Age range

20 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Fernanda Rossi Paolillo

São Carlos, São Paulo, 970, Brazil

About this study

PDT uses a non-toxic drug that is activated by exposure to light in the presence of oxygen. The excited state this drug transfers energy or electrons to ground state molecular oxygen producing cytotoxic effects on cell. There are productions of reactive oxygen species (ROS) and disrupts several of the cell's functions. This results in bacterial disinfection. In order to perform the PDT on the oral cavity, a device based on blue LED with transparent acrylic diffuser tip and cylindrical shape was developed.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • non-users of any antibiotic therapy
  • those who do not perform any oral hygiene, such as flossing, brushing and antiseptic mouthwash
  • those who performed 12-hour fasting prior the treatment and measurements

Exclusion criteria

  • oral cancer
  • smoking habits
  • pregnancy
  • patients with partial or total dentures
  • orthodontic brackets users

Treatment and study plan

mouthwash with curcumin

Drug

Mouthwash with 20 ml of curcumin solution for 5 minutes

blue LED illumination

Device

Oral cavity was illuminated with blue light for 5 minutes

Primary outcomes

  1. Microbiological analysis by the total number of colony-forming units (CFU).

    Time frame: Two hours

    Two saliva samples from each volunteer were collected. The saliva samples underwent serial dilutions and 100-microliters aliquots were plated on brain heart infusion agar plates (in duplicate) and then incubated under microaerophilic conditions. After incubation, the total number of colony-forming units (CFU) was determined.

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Collaborators

  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Fundação de Amparo à Pesquisa do Estado de São Paulo

Registry information

Official study title

PDT With Blue Light and Curcumin for Oral Disinfection

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Jun 2, 2014
Registry last updated
Jun 3, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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