Phenotyping of Patients With Polycystic Ovary Syndrome

Primary outcomes

1. Prevalence of obesity

   Time frame: Up to 12 months

   The prevalence of obesity indicates the proportion of obese individuals in a population (a country, a region, a school, etc.) at a given time.

   It is often expressed as a percentage.

   Example:

   If, in a region of 1,000 inhabitants, 200 people are obese,

   → the prevalence of obesity is 20%.

2. Biological Indicators of Insulin Resistance

   Time frame: Up to 12 months

   Biological Indicators of Insulin Resistance:

   • Fasting Blood Glucose (Blood Sugar) Measured after 8-12 hours of fasting. Normal: ~0.70 to 1.00 g/L (3.9-5.6 mmol/L) Abnormal: ≥1.00 g/L may suggest a disorder
   • Fasting Insulin Indicates how much insulin the body produces at rest.

   Normal (approx.): 2 to 10 µIU/mL High: > 10-12 µIU/mL → suspected insulin resistance

   • HOMA-IR Index (most commonly used)

   Calculated with:

   fasting blood glucose × fasting insulin ÷ 22.5 (in mmol/L)

   Common interpretation:

   < 2: normal insulin sensitivity 2-2.9: possible insulin resistance

   ≥ 3: probable insulin resistance